Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC

被引：4
作者：
Li, Jing-jing [1 ]
Ru, Zi-xuan [1 ]
Yang, Xu [1 ]
Sun, Jing-xue [1 ]
Wu, Yan-mei-zhi [1 ]
Yang, Xiao-yao [2 ]
Hou, Bo-yu [1 ]
Xue, Bing [1 ]
Ding, Chao [3 ]
Qiao, Hong [1 ,4 ]
机构：
[1] Harbin Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Harbin 150086, Heilongjiang, Peoples R China
[2] Heilongjiang Prov Hosp, Dept Sci & Educ, Harbin 150036, Heilongjiang, Peoples R China
[3] Second Affiliated Hosp Harbin Med Univ, Dept Gen Surg, Affiliated Hosp 2, Harbin 150086, Heilongjiang, Peoples R China
[4] Harbin Med Univ, NHC Key Lab Etiol & Epidemiol, 157 Baojian Rd,Nangang Dist, Harbin 150081, Heilongjiang, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Iodine; PTC; Circ_0004851; miR-296-3p; FGF11; Tumor development; PAPILLARY THYROID-CARCINOMA; CANCER INCIDENCE; SUPPLEMENTATION; ASSOCIATION; PROGRESSION; INVASION; MUTATION; URINARY; TRENDS; SERUM;
D O I：
10.1186/s12967-024-05405-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine's biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
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页数：21
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