Carbamoyl 1,4-Dihydropyridine Derivatives: Synthesis and Impressive Antidiabetic Activity

被引：0

作者：

Mathakiya, A. ^{[1
]}

Dubal, G. G. ^{[1
]}

Kapadiya, K. ^{[1
]}

Raval, K. ^{[2
,3
]}

Dhalani, J. ^{[1
]}

机构：

[1] RK Univ, Sch Sci, Dept Chem, Rajkot 360020, India

[2] RK Univ, Sch Pharm, Rajkot 360020, India

[3] Charotar Univ Sci & Technol, Ramanbhai Patel Coll Pharm, Changa 388421, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 05期

关键词：

dihydropyridines; Dolutegravir; antidiabetic activity; alpha-amylase inhibitory assay; DNSA assay; PYRIDINE; AMYLASE;

D O I：

10.1134/S1070428024050166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4-Dihydropyridine is known as one of the most important heterocyclic frameworks found in numerous pharmaceuticals and drugs. A series of novel methyl 5-[(substituted phenyl)carbamoyl]-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylates were synthesized by an in situ two-step procedure, starting from 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid. The compositions and structures of the synthesized diverse compounds were confirmed by elemental analysis and IR and H-1 and C-13 NMR spectroscopy and mass spectrometry. Screening for in vitro alpha-amylase inhibitor activity revealed a high inhibitory activity of methyl 1-(2,2-dimethoxyethyl)-3-methoxy-5-[(4-methoxyphenyl)carbamoyl]-4-oxo-1,4-dihydro pyridine-2-carboxylate, comparable with that of the standard drug Acarbose (IC50 = 28.83 and 26.81 mu g/mL, respectively).

引用

页码：943 / 949

页数：7

共 35 条

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