Synthesis of 3,4,5-Trisubstituted 1,2,4-Triazoles via I2-Catalyzed Cycloaddition of Amidines with Hydrazones

被引：1
作者：
Li, Xing [1 ]
Yuan, Xinyufei [1 ]
Wu, Yuting [1 ]
Guo, Honghong [1 ]
Liu, Qiang [1 ]
Huang, Shuangping [1 ]
机构：
[1] Taiyuan Univ Technol, Coll Biomed Engn, Taiyuan 030024, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 08期
关键词：
ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; N-TOSYLHYDRAZONES; S-TRIAZOLES; 1,3,4-OXADIAZOLES; HYDRAZIDES; DESIGN; FUNCTIONALIZATION; 1,2,4-OXADIAZOLES; CYCLIZATION;
D O I：
10.1021/acs.joc.3c02637
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and practical method for the construction of various 3,4,5-trisubstituted 1,2,4-triazoles via I2-catalyzed cycloaddition of N-functionalized amidines with hydrazones is reported. This strategy features cheap and readily available catalyst and starting materials, broader substrate scope, and moderate-to-good yields. The mechanism study shows that the existence of hydrogen on the nitrogen of hydrazones is crucial for this transformation.
引用
收藏
页码：5277 / 5286
页数：10
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