Targeting Lipoprotein(a) to reduce residual risk in high risk atherosclerotic cardiovascular disease patients

被引：0

作者：

Waring, Ashley A. ^{[1
]}

Morris, Pamela B. ^{[1
]}

机构：

[1] Med Univ South Carolina, Cardiol, Charleston, SC USA

来源：

REVISTA DE LA FEDERACION ARGENTINA DE CARDIOLOGIA | 2023年 / 52卷 / 02期

关键词：

Lipoprotein(a); residual risk; secondary prevention; antisense oligonucleotide; small-interfering RNA; EXTENDED-RELEASE NIACIN; OXIDIZED PHOSPHOLIPIDS; PLASMINOGEN-ACTIVATOR; APOLIPOPROTEIN(A); CORONARY; OUTCOMES; ASSOCIATION; TERM; CALCIFICATION; HERITABILITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormal lipoprotein(a) [Lp(a)] levels are associated with an elevated risk of cardiovascular events. Lp(a) has been used to risk stratify primary prevention patients, and more recently, it has been identified as a marker of residual risk in secondary prevention patients. Treatment for these patients is limited to LDL lowering therapies and optimizing lifestyle changes. Novel nucleic acid therapies that target Lp(a) production, including antisense oligonucleotide (pelacarsen) and small-interfering RNA (olpasiran), are safe and markedly lower Lp(a) levels. Phase 3 trials, HORIZON and OCEAN(a), are currently studying if significant reduction in Lp(a) with these drugs will lower major adverse cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD).

引用

页码：59 / 64

页数：6

共 72 条

[1]

AUSTIN MA, 1992, AM J HUM GENET, V51, P829

[2] A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma [J].

Bergmark, Claes ;

Dewan, Asheesh ;

Orsoni, Alexina ;

Merki, Esther ;

Miller, Elizabeth R. ;

Shin, Min-Jeong ;

Binder, Christoph J. ;

Horkko, Sohvi ;

Krauss, Ronald M. ;

Chapman, M. John ;

Witztum, Joseph L. ;

Tsimikas, Sotirios .

JOURNAL OF LIPID RESEARCH, 2008, 49 (10) :2230-2239

[3] Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy [J].

Boden, William E. ;

Probstfield, Jeffrey L. ;

Anderson, Todd ;

Chaitman, Bernard R. ;

Desvignes-Nickens, Patrice ;

Koprowicz, Kent ;

McBride, Ruth ;

Teo, Koon ;

Weintraub, William .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) :2255-2267

[4] Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis[S] [J].

Boffa, Michael B. ;

Marar, Tanya T. ;

Yeang, Calvin ;

Viney, Nicholas J. ;

Xia, Shuting ;

Witztum, Joseph L. ;

Koschinsky, Marlys L. ;

Tsimikas, Sotirios .

JOURNAL OF LIPID RESEARCH, 2019, 60 (12) :2082-2089

[5] Thematic Review Series: Lipoprotein (a): Coming of Age at Last Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease? [J].

Boffa, Michael B. ;

Koschinsky, Marlys L. .

JOURNAL OF LIPID RESEARCH, 2016, 57 (05) :745-757

[6] Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies A Mendelian Randomization Analysis [J].

Burgess, Stephen ;

Ference, Brian A. ;

Staley, James R. ;

Freitag, Daniel F. ;

Mason, Amy M. ;

Nielsen, Sune F. ;

Willeit, Peter ;

Young, Robin ;

Surendran, Praveen ;

Karthikeyan, Savita ;

Bolton, Thomas R. ;

Peters, James E. ;

Kamstrup, Pia R. ;

Tybjaerg-Hansen, Anne ;

Benn, Marianne ;

Langsted, Anne ;

Schnohr, Peter ;

Vedel-Krogh, Signe ;

Kobylecki, Camilla J. ;

Ford, Ian ;

Packard, Chris ;

Trompet, Stella ;

Jukema, J. Wouter ;

Sattar, Naveed ;

Di Angelantonio, Emanuele ;

Saleheen, Danish ;

Howson, Joanna M. M. ;

Nordestgaard, Borge G. ;

Butterworth, Adam S. ;

Danesh, John .

JAMA CARDIOLOGY, 2018, 3 (07) :619-627

[7] A Replicated, Genome-Wide Significant Association of Aortic Stenosis With a Genetic Variant for Lipoprotein(a) Meta-Analysis of Published and Novel Data [J].

Cairns, Benjamin J. ;

Coffey, Sean ;

Travis, Ruth C. ;

Prendergast, Bernard ;

Green, Jane ;

Engert, James C. ;

Lathrop, Mark ;

Thanassoulis, George ;

Clarke, Robert .

CIRCULATION, 2017, 135 (12) :1181-1183

[8] PRONOUNCED LOWERING OF SERUM LEVELS OF LIPOPROTEIN LP(A) IN HYPERLIPEMIC SUBJECTS TREATED WITH NICOTINIC-ACID [J].

CARLSON, LA ;

HAMSTEN, A ;

ASPLUND, A .

JOURNAL OF INTERNAL MEDICINE, 1989, 226 (04) :271-276

[9] Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene [J].

Coassin, Stefan ;

Kronenberg, Florian .

ATHEROSCLEROSIS, 2022, 349 :17-35

[10] Towards an SI-Traceable Reference Measurement System for Seven Serum Apolipoproteins Using Bottom-Up Quantitative Proteomics: Conceptual Approach Enabled by Cross-Disciplinary/Cross-Sector Collaboration [J].

Cobbaert, Christa M. ;

Althaus, Harald ;

Brkovic, Ilijana Begcevic ;

Ceglarek, Uta ;

Coassin, Stefan ;

Delatour, Vincent ;

Deprez, Liesbet ;

Dikaios, Ioannis ;

Dittrich, Julia ;

Hoofnagle, Andrew N. ;

Kostner, Gerhard M. ;

Kronenberg, Florian ;

Kuklenyik, Zsusanna ;

Prinzing, Urban ;

Vesper, Hubert W. ;

Zegers, Ingrid ;

Ruhaak, L. Renee .

CLINICAL CHEMISTRY, 2021, 67 (03) :478-489

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