Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent

被引：0

作者：

Cao X. ^{[1
]}

Ji S. ^{[2
]}

Kuang W. ^{[1
]}

Liao A. ^{[1
]}

Lan P. ^{[1
]}

Zhang J. ^{[1
]}

机构：

[1] Guangxi Key Laboratory for Polysaccharide Materials and their Modification, College of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning, 530006, Guangxi

[2] Guangxi Tobacco Monopoly Bureau, Nanning, 530006, Guangxi

来源：

Huagong Xuebao/CIESC Journal | 2019年 / 70卷 / 03期

关键词：

Apelblat equation; Azithromycin dihydrate; Solubility; Ternary phase diagram; Water activity of transformation;

D O I：

10.11949/j.issn.0438-1157.20180910

中图分类号：

学科分类号：

摘要：

The solubility of azithromycinin water+isopropanol and propanone+water solvent mixtures were measured at temperatures from 293.15 K to 323.15 K by an analytical method. The water activity of transformation at 293.15, 298.15, 303.15 and 308.15 K were measured, and the phase diagram of alcohol- azithromycin -water at that temperature was obtained through solubility property. The solubility data were correlated by the modified Apelblat equation, λh equation and van't Hoff equation. The results showed that the solubility of azithromycin dihydrate obviously increased with the increase of temperature and the volume fraction of isopropanol and propanone, and the water activity of transformation increased and the coexist area decreased with the increase of temperature. The modified Apelblat equation was the best choice in the correlation of the solubility data. © All Right Reserved.

引用

页码：817 / 829

页数：12

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