Targeting glutamate metabolism in chronic lung diseases

被引:2
作者
Guo, Zhihou [1 ]
Yan, Furong [1 ]
机构
[1] Fujian Med Univ, Affiliated Hosp 2, Clin Ctr Mol Diag & Therapy, Quanzhou, Fujian, Peoples R China
来源
CLINICAL AND TRANSLATIONAL DISCOVERY | 2024年 / 4卷 / 02期
基金
中国国家自然科学基金;
关键词
amino acid; chronic lung diseases; glutamate; glutamate transports; metabolism dysfunction; CYSTINE/GLUTAMATE ANTIPORTER; SYSTEM X(C)(-); TRANSPORTERS; RECEPTORS; RELEASE; BIOLOGY; PLASMA; INJURY; CELLS;
D O I
10.1002/ctd2.294
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Amino acids are necessary for all life forms, which play various roles. Disorder of amino acid metabolism is now considered an important driving mechanism in diverse pulmonary conditions, particularly chronic lung diseases like chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and lung cancer. Glutamate actively participates in multiple vital biological processes, while the intricate glutamate metabolism, glutamate receptors and glutamate transporters assume crucial regulatory functions in the development of chronic lung diseases. This review aims to discuss the relationship between glutamate dysfunction and chronic lung diseases. By discussing the physiological and pathological function of glutamate, we probe the potential drug targets for chronic lung diseases in the glutamate pathway. Amino acid metabolism is crucial in chronic lung diseases, impacting inflammation, tissue repair, regeneration, nutrition, and muscle function. Glutamate metabolism impacts chronic lung diseases development by regulating inflammation, oxidative stress and tissue repair processes. Intervening in glutamate metabolism or modulating glutamate levels through glutamate receptors and transporters can have therapeutic effects on chronic lung diseases. image
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页数:11
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