The DNA damage response - from cell biology to human disease

被引：19

作者：

Lam, Fred C. ^{[1
]}

机构：

[1] McMaster Univ, Hamilton Gen Hosp, Fac Hlth Sci, Div Neurosurg, Hamilton, ON L8L 2X2, Canada

来源：

JOURNAL OF TRANSLATIONAL GENETICS AND GENOMICS | 2022年 / 6卷 / 02期

关键词：

DNA damage response; DNA damage repair; mutagenesis; cancer; neurodegeneration; neuropsychiatric disorders; premature aging; clinical outcomes; FANCONI-ANEMIA PATHWAY; MISMATCH REPAIR DEFICIENCY; STRAND BREAK REPAIR; TRANSCRIPTION-COUPLED REPAIR; XERODERMA-PIGMENTOSUM; ATAXIA-TELANGIECTASIA; TARGETED DISRUPTION; COCKAYNE-SYNDROME; MOUSE MODEL; GENOMIC INSTABILITY;

D O I：

10.20517/jtgg.2021.61

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Maintenance of DNA integrity is crucial for faithful transmission of the genetic code from generation to generation. Our genetic code is constantly under attack from both endogenous and exogenous sources of DNA damage. To ensure genome stability, cells have developed elegant DNA damage repair mechanisms. Defects in DNA damage repair have been linked to several human diseases including promoting oncogenesis, heritable neurodegenerative and neuromuscular diseases caused by unstable DNA repeats, neuropathies and myopathies caused by mutations and rearrangements in mitochondrial DNA, neuropsychiatric disorders, and heritable premature aging syndromes. This review will discuss our current understanding of how these underlying errors in DNA repair contribute to the clinical outcomes of patients who present with these diseases.

引用

页码：204 / 222

页数：19

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