Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights

被引：2
作者：
Soleimani, Atena [1 ]
Saeedi, Nikoo [2 ]
Al-Asady, Abdulridha Mohammed [3 ]
Nazari, Elnaz [4 ]
Hanaie, Reyhane [4 ]
Khazaei, Majid [5 ]
Ghorbani, Elnaz [6 ]
Akbarzade, Hamed [1 ]
Ryzhikov, Mikhail [7 ]
Avan, Amir [8 ]
Mehr, Seyed Mahdi Hasanian [9 ]
机构：
[1] Mashhad Univ Med Sci, Dept Biochem, Razavi Khorasan, Mashhad, Iran
[2] Islamic Azad Univ, Med Sch, Mashhad, Iran
[3] Univ Warith Al Anbiyaa, Dept Pharmacol, Karbala, Iraq
[4] Mashhad Univ Med Sci, Dept Physiol, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Dept Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran
[6] Mashhad Univ Med Sci, Dept Microbiol, Mashhad, Razavi Khorasan, Iran
[7] St Louis Univ, Dept Biochem, St Louis, MO USA
[8] Mashhad Univ Med Sci, Dept Genet, Mashhad, Razavi Khorasan, Iran
[9] Mashhad Univ Med Sci, Dept Biochem, Mashhad, Razavi Khorasan, Iran
来源：
CURRENT PHARMACEUTICAL DESIGN | 2024年 / 30卷 / 18期
关键词：
LGR5; ALDH; CD166; CD133; CD44; Cancer stem cell; Colon cancer; ALDEHYDE DEHYDROGENASE 1; COLON-CANCER; ADJUVANT CHEMOTHERAPY; CLINICAL GUIDELINES; CD133; EXPRESSION; POOR-PROGNOSIS; MARKER CD133; CD44; LGR5; SIRT1;
D O I：
10.2174/0113816128291321240329050945
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.
引用
收藏
页码：1386 / 1397
页数：12
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