Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review

被引：0

作者：

Wafriy, Che Ismail ^{[1
,2
]}

Nor-Ashikin, Mohamed Noor Khan ^{[1
,2
]}

Kamsani, Yuhaniza Shafinie ^{[1
,2
]}

Muid, Suhaila Abd ^{[3
]}

Sarbandi, Mimi Sophia ^{[1
,4
]}

机构：

[1] Univ Teknol MARA, Jalan Hosp, Fac Med, Maternofetal & Embryo MatE Res Grp, Sungai Buloh 47000, Selangor, Malaysia

[2] Univ Teknol MARA, Jalan Hosp, Fac Med, Dept Physiol, Sungai Buloh Campus, Sungai Buloh 47000, Selangor, Malaysia

[3] Univ Teknol MARA, Jalan Hosp, Fac Med, Dept Biochem & Mol Med, Sungai Buloh Campus, Sungai Buloh 47000, Selangor, Malaysia

[4] Univ Teknol MARA, Fac Appl Sci, Perak Branch, Tapah Rd,Tapah Campus, Shah Alam 35400, Malaysia

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2025年 / 203卷 / 01期

关键词：

Iron homeostasis; Ferrous iron; Ferric iron; Ferritin; Transferrin; Allergic asthma; OXIDATIVE STRESS; AIRWAY INFLAMMATION;

D O I：

10.1007/s12011-024-04183-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of the immune oxidative stress response in the pathophysiology and pathogenesis of allergic asthma is well documented. However, reports on the role of iron homeostasis in allergic asthma is scarce. Therefore, this study aims to identify iron-related genes and proteins in mouse models of allergic asthma. Related articles were identified from SCOPUS and Web of Science databases. The article search was limited to publications in English, within a 10-year period (2014 - 2023, up to 16 August 2023) and original/research papers. All identified articles were screened for eligibility using the inclusion and exclusion criteria. All eligible articles were quality appraised prior to data extraction. Five studies were selected for data extraction. Based on the extracted data, three themes and seven subthemes related to iron homeostasis were identified. The type of samples and analytical methods used were also identified. In conclusion, our study elucidates that iron-related proteins are regulated in animal models of allergic asthma. However, the currently available data do not allow us to conclude whether the disease model resulted in iron accumulation or depletion. Therefore, further studies with other related markers should be conducted.

引用

页码：334 / 345

页数：12

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