Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma

被引：5

作者：

Ford, Maria L. ^{[1
,2
]}

Ruwanpathirana, Anushka ^{[1
,2
]}

Lewis, Brandon W. ^{[1
]}

Britt Jr, Rodney D. ^{[1
,3
]}

机构：

[1] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Perinatal Res, Columbus, OH 43215 USA

[2] Ohio State Univ, Coll Med, Biomed Sci Grad Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 07期

基金：

美国国家卫生研究院;

关键词：

aging; airway inflammation; asthma; corticosteroid insensitivity; senescence; ALLERGIC AIRWAY DISEASE; GLUCOCORTICOID-RECEPTOR-BETA; CELLULAR SENESCENCE; SMOOTH-MUSCLE; NUCLEAR TRANSLOCATION; BINDING-AFFINITY; POOR RESPONSE; INFLAMMATION; CELLS; MANAGEMENT;

D O I：

10.3390/ijms24076347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asthma in elderly populations is an increasing health problem that is accompanied by diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs, corticosteroids are commonly used to reduce lung inflammation, improve lung function, and manage disease symptoms in asthma. Although effective for most individuals, older patients are more insensitive to corticosteroids, making it difficult to manage asthma in this population. With the number of individuals older than 65 continuing to increase, it is important to understand the distinct mechanisms that promote corticosteroid insensitivity in the aging lung. In this review, we discuss corticosteroid insensitivity in asthma with an emphasis on mechanisms that contribute to persistent inflammation and diminished lung function in older individuals.

引用

页数：14

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