PHARMACOLOGICAL TREATMENT OF NONRESPONDERS FOLLOWING BARIATRIC SURGERY: A NARRATIVE REVIEW OF THE CURRENT EVIDENCE

被引:7
作者
Vinciguerra, Federica [1 ,3 ]
Romeo, Luana Maria Catena [1 ]
Frittitta, Lucia [1 ,2 ]
Baratta, Roberto [2 ]
机构
[1] Univ Catania, Dept Clin & Expt Med, Endocrinol, Catania, Italy
[2] Garibaldi Hosp, Diabet Obes & Dietet Ctr, Catania, Italy
[3] Univ Catania, Dept Clin & Expt Med, Endocrinol, Catania, Italy
来源
MINERVA ENDOCRINOLOGY | 2021年
关键词
bariatric surgery; weight loss; pharmacotherapy; non-responder; insufficient weight loss; weight regain;
D O I
10.23736/S2724-6507.21.03311-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Obesity is a complex chronic disease and requires a long-term multidisciplinary management. Even patients undergoing bariatric surgery, one the most effective treatments for obesity, can have insufficient weight loss (IWL) than expected (primary non responder) or weight regain (WR) after a successful primary procedure (secondary non responder). A poor response represents a challenge of bariatric surgery that can induce persistence or recurrence of obesity-related comorbidities, prejudicing benefits of surgery. Increasing evidence suggests that weight loss medications represent a useful strategy in obesity care also after bariatric surgery procedures. Evidence acquisition: This narrative review summarizes the evidence concerning anti-obesity therapy in the management of no-responders to primary bariatric surgery. Available data on liraglutide (one randomized double-blind placebo-controlled trial, three prospective and three retrospective studies), naltrexone/bupropion (three retrospective studies), orlistat (one case control prospective and one retrospective studies) and topiramate and phentermine (5 retrospective studies) have been considered. Evidence synthesis: Available data suggest that weight loss medications could offer a significant adjunctive benefit to lifestyle and behavioral modifications in the life-long management of obesity. Conclusions: Newer treatment modalities including the use of anti-obesity drugs provide patients and healthcare providers with more options in the management of poor response after bariatric surgery.
引用
收藏
页数:26
相关论文
共 64 条
  • [11] Long-term Outcomes of Bariatric Surgery A National Institutes of Health Symposium
    Courcoulas, Anita P.
    Yanovski, Susan Z.
    Bonds, Denise
    Eggerman, Thomas L.
    Horlick, Mary
    Staten, Myrlene A.
    Arterburn, David E.
    [J]. JAMA SURGERY, 2014, 149 (12) : 1323 - 1329
  • [12] Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
    Cummings, DE
    Weigle, DS
    Frayo, RS
    Breen, PA
    Ma, MK
    Dellinger, EP
    Purnell, JQ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (21) : 1623 - 1630
  • [13] Outcomes of a Third Bariatric Procedure for Inadequate Weight Loss
    Daigle, Christopher R.
    Aminian, Ali
    Romero-Talamas, Hector
    Corcelles, Ricard
    Mackey, Jennifer
    Rogula, Tomasz
    Brethauer, Stacy A.
    Schauer, Philip R.
    [J]. JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS, 2014, 18 (03)
  • [14] Incretin-based therapies for obesity treatment
    de Mello, Aline Haas
    Pra, Morgana
    Cardoso, Larissa Colonetti
    Schraiber, Rosiane de Bona
    Rezin, Gislaine Tezza
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2015, 64 (09): : 967 - 981
  • [15] Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP
    Di Lorenzo, Nicola
    Antoniou, Stavros A.
    Batterham, Rachel L.
    Busetto, Luca
    Godoroja, Daniela
    Iossa, Angelo
    Carrano, Francesco M.
    Agresta, Ferdinando
    Alarcon, Isaias
    Azran, Carmil
    Bouvy, Nicole
    Balague Ponz, Carmen
    Buza, Maura
    Copaescu, Catalin
    De Luca, Maurizio
    Dicker, Dror
    Di Vincenzo, Angelo
    Felsenreich, Daniel M.
    Francis, Nader K.
    Fried, Martin
    Prats, Berta Gonzalo
    Goitein, David
    Halford, Jason C. G.
    Herlesova, Jitka
    Kalogridaki, Marina
    Ket, Hans
    Morales-Conde, Salvador
    Piatto, Giacomo
    Prager, Gerhard
    Pruijssers, Suzanne
    Pucci, Andrea
    Rayman, Shlomi
    Romano, Eugenia
    Sanchez-Cordero, Sergi
    Vilallonga, Ramon
    Silecchia, Gianfranco
    [J]. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2020, 34 (06): : 2332 - 2358
  • [16] Re-emergence of diabetes after gastric bypass in patients with mid- to long-term follow-up
    DiGiorgi, Mary
    Rosen, Daniel J.
    Choi, Jenny J.
    Milone, Luca
    Schrope, Beth
    Olivero-Rivera, Lorraine
    Restuccia, Nancy
    Yuen, Sara
    Fisk, McKenzie
    Inabnet, William B.
    Bessler, Marc
    [J]. SURGERY FOR OBESITY AND RELATED DISEASES, 2010, 6 (03) : 249 - 253
  • [17] Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass
    Dirksen, C.
    Jorgensen, N. B.
    Bojsen-Moller, K. N.
    Kielgast, U.
    Jacobsen, S. H.
    Clausen, T. R.
    Worm, D.
    Hartmann, B.
    Rehfeld, J. F.
    Damgaard, M.
    Madsen, J. L.
    Madsbad, S.
    Holst, J. J.
    Hansen, D. L.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2013, 37 (11) : 1452 - 1459
  • [18] GLUCAGONLIKE PEPTIDE-I STIMULATES INSULIN GENE-EXPRESSION AND INCREASES CYCLIC-AMP LEVELS IN A RAT ISLET CELL-LINE
    DRUCKER, DJ
    PHILIPPE, J
    MOJSOV, S
    CHICK, WL
    HABENER, JF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) : 3434 - 3438
  • [19] Food quality, physical activity, and nutritional follow-up as determinant of weight regain after Roux-en-Y gastric bypass
    Freire, Rachel Horta
    Borges, Mariane Curado
    Alvarez-Leite, Jacqueline Isaura
    Toulson Davisson Correia, Maria Isabel
    [J]. NUTRITION, 2012, 28 (01) : 53 - 58
  • [20] Effectiveness and tolerability of liraglutide in patients with type 2 diabetes mellitus and obesity after bariatric surgery
    Gorgojo-Martinez, Juan J.
    Feo-Ortega, Gara
    Serrano-Moreno, Clara
    [J]. SURGERY FOR OBESITY AND RELATED DISEASES, 2016, 12 (10) : 1856 - 1865