Would New SARS-CoV-2 Variants Change the War against COVID-19?

被引：3

作者：

Redwan, Elrashdy M. ^{[1
,2
]}

Elrashdy, Fatma ^{[3
]}

Aljabali, Alaa A. A. ^{[4
]}

Baetas-da-Cruz, Wagner ^{[5
]}

Barh, Debmalya ^{[6
,7
]}

Brufsky, Adam M. ^{[8
]}

Hassan, Sk. Sarif ^{[9
]}

Lundstrom, Kenneth ^{[10
]}

Serrano-Aroca, Angel ^{[11
]}

Takayama, Kazuo ^{[12
]}

Tambuwala, Murtaza M. ^{[13
]}

Uhal, Bruce D. ^{[14
]}

Uversky, Vladimir N. ^{[1
,15
,16
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, POB 80203, Jeddah 21589, Saudi Arabia

[2] City Sci Res & Technol Applicat, Genet Engn & Biotechnol Res Inst, Prot Res Dept, Therapeut & Protect Prot Lab, Alexandria 21934, Egypt

[3] Cairo Univ, Dept Endem Med & Hepatogastroenterol, Cairo 12111, Egypt

[4] Yarmouk Univ, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Irbid 566, Jordan

[5] Fed Univ Rio De Janeiro UFRJ, Coll Med, Ctr Expt Surg, Translat Lab Mol Physiol, BR-21941901 Rio De Janeiro, RJ, Brazil

[6] Inst Integrat Om & Appl Biotechnol IIOAB, Purba Medinipur 721172, W Bengal, India

[7] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Genet Ecol & Evolucao, Lab Genet Celular & Mol, BR-31270901 Belo Horizonte, MG, Brazil

[8] Univ Pittsburgh, UPMC Hillman Canc Ctr, Sch Med, Dept Med,Div Hematol Oncol, Pittsburgh, PA 15232 USA

[9] Pingla Thana Mahavidyalaya, Dept Math, Maligram 721140, W Bengal, India

[10] PanTherapeut, Rte Lavaux 49, CH-1095 Lutry, Switzerland

[11] Univ Catolica Valencia San Vicente Martir, Ctr Invest Traslac San Alberto Magno, Biomat & Bioengn Lab, Valencia 46001, Spain

[12] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto 6068507, Japan

[13] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, North Ireland

[14] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

[15] Univ S Florida, Morsani Coll Med, Dept Mol Med, Tampa, FL 33612 USA

[16] Univ S Florida, USF Hlth Byrd Alzheimers Res Inst, Morsani Coll Med, Tampa, FL 33612 USA

来源：

EPIDEMIOLOGIA | 2022年 / 3卷 / 02期

关键词：

SARS-CoV-2; COVID-19; variant; sublineage; transmission; immunity; infection; vaccination; non-pharmaceutical interventions; HEALTH-CARE WORKERS; VACCINE; CORONAVAC; MULTICENTER; IMMUNITY; ENGLAND; BRAZIL;

D O I：

10.3390/epidemiologia3020018

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? (iii) Which are the factors responsible for this decay in neutralizing antibodies? (iv) What strategy could be adapted to develop long-term herd immunity? (v) Is the Spike protein the only vaccine target or is a vaccine cocktail better?

引用

页码：229 / 237

页数：9

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