Signaling pathways implicated in enhanced stem/progenitor cell differentiation on electroactive scaffolds

被引：15
作者：
Heng B.C. [1 ,2 ]
Bai Y. [3 ]
Li X. [3 ]
Meng Y. [4 ]
Zhang X. [4 ,5 ]
Deng X. [3 ,5 ]
机构：
[1] Central Laboratory, Peking University School and Hospital of Stomatology, Beijing
[2] School of Medical and Life Sciences, Sunway University, Selangor Darul Ehsan
[3] Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing
[4] Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing
[5] National Engineering Laboratory for Digital and Material Technology of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing Laboratory of Biomedical Materials & Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital
来源：
Smart Materials in Medicine | 2022年 / 3卷
基金：
中国国家自然科学基金;
关键词：
Charge; Differentiation; Electrical; Matrix; Progenitor; Scaffold; Stem; Substrata;
D O I：
10.1016/j.smaim.2021.11.003
中图分类号：
学科分类号：
摘要：
Cells are naturally surrounded by an electroactive extracellular matrix in vivo, which is composed of a diverse array of charged molecules such as glycosaminoglycans and proteoglycans, together with piezoelectric collagen fibers capable of generating electrical signals in response to mechanical stimuli. In recent years, electroactive scaffold materials have attracted much attention in tissue engineering and regenerative medicine applications, as a biomimetic strategy to recapitulate the natural physiological electrical microenvironment in vivo, which could enhance the differentiation of stem/progenitor cells into specific lineages, thus facilitating tissue repair and regeneration. The key to improving the functional design of electroactive scaffold biomaterials would be to understand the various intracellular signaling pathways that are activated by electrical stimuli. Therefore, this review critically examines the effects of electrical stimuli and/or scaffolds with electroactive properties on directing stem/progenitor cells towards the osteogenic, neurogenic and other lineages, with particular focus on the molecular signaling pathways involved. © 2021
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页码：4 / 11
页数：7
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