De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1-2 N0 breast cancer treated with mastectomy: nationwide registry study (BOOG 2013-07)

被引：1
作者：
de Wild, Sabine R. [1 ,22 ]
van Roozendaal, Lori M. [2 ]
de Wilt, Johannes H. W. [3 ]
van Dalen, Thijs [4 ]
van der Hage, Jos A. [5 ,6 ]
van Duijnhoven, Frederieke H.
Simons, Janine M. [7 ]
Schipper, Robert-Jan [8 ]
de Munck, Linda [9 ]
van Kuijk, Sander M. J. [10 ]
Boersma, Liesbeth J. [11 ]
Linn, Sabine C. [12 ]
Lobbes, Marc B., I [13 ]
Poortmans, Philip M. P. [14 ,15 ]
Tjan-Heijnen, Vivianne C. G. [16 ]
van de Vijver, Koen K. B. T. [17 ,18 ]
de Vries, Jolanda [19 ]
Westenberg, A. Helen [20 ]
Strobbe, Luc J. A. [21 ]
Smidt, Marjolein L. [1 ]
机构：
[1] Maastricht Univ, Med Ctr, Dept Surg, Grow Sch Oncol & Reprod, Maastricht, Netherlands
[2] Zuyderland Med Ctr, Dept Surg, Heerlen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands
[4] Erasmus MC, Dept Surg, Rotterdam, Netherlands
[5] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands
[6] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands
[7] Erasmus MC, Dept Radiotherapy, Rotterdam, Netherlands
[8] Catharina Hosp, Dept Surg, Eindhoven, Netherlands
[9] Netherlands Comprehens Canc Org IKNL, Dept Res & Dev, Utrecht, Netherlands
[10] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands
[11] Maastricht Univ, Med Ctr, Dept Radiat Oncol Maastro, Grow Sch Oncol & Reprod, Maastricht, Netherlands
[12] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands
[13] Zuyderland Med Ctr, Dept Med Imaging, Sittard Geleen, Netherlands
[14] Iridium Netwerk, Dept Radiat Oncol, Antwerp, Belgium
[15] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium
[16] Maastricht Univ, Med Ctr, Dept Med Oncol, Maastricht, Netherlands
[17] Netherlands Canc Inst Antoni Van Leeuwenhoek, Dept Pathol, Amsterdam, Netherlands
[18] Univ Hosp Ghent, Canc Res Inst Ghent, Dept Pathol, Ghent, Belgium
[19] Tilburg Univ, Dept Psychol & Hlth, Tilburg, Netherlands
[20] Radiotherapiegroep Arnhem, Dept Radiat Oncol, Arnhem, Netherlands
[21] Canisius Wilhelmina Hosp, Dept Surg, Nijmegen, Netherlands
[22] Maastricht Univ, Med Ctr, Dept Surg, POB 5800, NL-6202 AZ Maastricht, Netherlands
来源：
BRITISH JOURNAL OF SURGERY | 2024年 / 111卷 / 04期
关键词：
FOLLOW-UP; CLINICAL-TRIALS; OLDER PATIENTS; PHASE-III; DISSECTION; RECURRENCE; RADIATION; SURVIVAL; OMISSION; ONCOLOGY;
D O I：
10.1093/bjs/znae077
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1-2 N0 breast cancer operated with breast-conserving surgery who have limited metastatic burden in the sentinel lymph node. The aim of this registry study was to provide insight into the oncological safety of omitting completion axillary treatment in patients operated with mastectomy who have limited-volume sentinel lymph node metastasis.Methods Women diagnosed in 2013-2014 with unilateral cT1-2 N0 breast cancer treated with mastectomy, with one to three sentinel lymph node metastases (pN1mi-pN1a), were identified from the Netherlands Cancer Registry, and classified by axillary treatment: no completion axillary treatment, completion axillary lymph node dissection, regional radiotherapy, or completion axillary lymph node dissection followed by regional radiotherapy. The primary endpoint was 5-year regional recurrence rate. Secondary endpoints included recurrence-free interval and overall survival, among others.Results In total, 1090 patients were included (no completion axillary treatment, 219 (20.1%); completion axillary lymph node dissection, 437 (40.1%); regional radiotherapy, 327 (30.0%); completion axillary lymph node dissection and regional radiotherapy, 107 (9.8%)). Patients in the group without completion axillary treatment had more favourable tumour characteristics and were older. The overall 5-year regional recurrence rate was 1.3%, and did not differ significantly between the groups. The recurrence-free interval was also comparable among groups. The group of patients who did not undergo completion axillary treatment had statistically significantly worse 5-year overall survival, owing to a higher percentage of non-cancer deaths.Conclusion In this registry study of patients with cT1-2 N0 breast cancer treated with mastectomy, with low-volume sentinel lymph node metastasis, the 5-year regional recurrence rate was low and comparable between patients with and without completion axillary treatment. The aim of this registry study was to provide insight into the oncological safety of omitting completion axillary treatment in patients with cT1-2 N0 breast cancer treated with mastectomy, who have limited sentinel lymph node involvement. The 5-year regional recurrence rate was low (overall 1.3%) and comparable between treatment groups. Omitting completion axillary treatment appears to be safe in selected patients.
引用
收藏
页数：10
相关论文
共 48 条
[41]  
van der Plas-Krijgsman WG, 2021, LANCET HEALTH LONGEV, V2, pE704
[42]   Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08) [J].
van Roozendaal, L. M. ;
Vane, M. L. G. ;
van Dalen, T. ;
van der Hage, J. A. ;
Strobbe, L. J. A. ;
Boersma, L. J. ;
Linn, S. C. ;
Lobbes, M. B. I. ;
Poortmans, P. M. P. ;
Tjan-Heijnen, V. C. G. ;
Van de Vijver, K. K. B. T. ;
de Vries, J. ;
Westenberg, A. H. ;
Kessels, A. G. H. ;
de Wilt, J. H. W. ;
Smidt, M. L. .
BMC CANCER, 2017, 17
[43]   The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch randomized controlled multicentre trial (BOOG 2013-07) [J].
van Roozendaal, L. M. ;
de Wilt, J. H. W. ;
van Dalen, T. ;
van der Hage, J. A. ;
Strobbe, L. J. A. ;
Boersma, L. J. ;
Linn, S. C. ;
Lobbes, M. B. I. ;
Poortmans, P. M. P. ;
Tjan-Heijnen, V. C. G. ;
Van de Vijver, K. K. B. T. ;
de Vries, J. ;
Westenberg, A. H. ;
Kessels, A. G. H. ;
Smidt, M. L. .
BMC CANCER, 2015, 15
[44]   Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy [J].
van Wely, B. J. ;
Teerenstra, S. ;
Schinagl, D. A. X. ;
Aufenacker, T. J. ;
de Wilt, J. H. W. ;
Strobbe, L. J. A. .
BRITISH JOURNAL OF SURGERY, 2011, 98 (03) :326-333
[45]   Sentinel Lymph Node Biopsy in Breast Cancer Ten-Year Results of a Randomized Controlled Study [J].
Veronesi, Umberto ;
Viale, Giuseppe ;
Paganelli, Giovanni ;
Zurrida, Stefano ;
Luini, Alberto ;
Galimberti, Viviana ;
Veronesi, Paolo ;
Intra, Mattia ;
Maisonneuve, Patrick ;
Zucca, Francesca ;
Gatti, Giovanna ;
Mazzarol, Giovanni ;
De Cicco, Concetta ;
Vezzoli, Dario .
ANNALS OF SURGERY, 2010, 251 (04) :595-600
[46]   Trends of Axillary Treatment in Sentinel Node-Positive Breast Cancer Patients Undergoing Mastectomy [J].
Verreck, Eline E. F. ;
van Steenhoven, Julia E. C. ;
Kuijer, Anne ;
van Maaren, Marissa C. ;
Simons, Janine M. ;
Siesling, Sabine ;
van Dalen, Thijs .
ANNALS OF SURGICAL ONCOLOGY, 2023, 30 (09) :5623-5632
[47]   Evolution in practice patterns of axillary management following mastectomy in patients with 1-2 positive sentinel nodes [J].
Weiss, Anna ;
Lin, Heather ;
Babiera, Gildy V. ;
Bedrosian, Isabelle ;
Shaitelman, Simona F. ;
Shen, Yu ;
Kuerer, Henry M. ;
Mittendorf, Elizabeth A. ;
Caudle, Abigail S. ;
Hunt, Kelly K. ;
Hwang, Rosa F. .
BREAST CANCER RESEARCH AND TREATMENT, 2019, 176 (02) :435-444
[48]   Extremely Low Incidence of Local-Regional Recurrences Observed Among T1-2 N1 (1 or 2 Positive SLNs) Breast Cancer Patients Receiving Upfront Mastectomy Without Completion Axillary Node Dissection [J].
Zaveri, Shruti ;
Everidge, Shlermine ;
FitzSullivan, Elizabeth ;
Hwang, Rosa ;
Smith, Benjamin D. ;
Lin, Heather ;
Shen, Yu ;
Lucci, Anthony ;
Teshome, Mediget ;
Sun, Susie X. X. ;
Hunt, Kelly K. ;
Kuerer, Henry M. .
ANNALS OF SURGICAL ONCOLOGY, 2023, 30 (12) :7015-7025
12345