The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer

被引：3

作者：

O'Neill, Ciara E. ^{[1
]}

Sun, Kai ^{[2
,3
]}

Sundararaman, Sugunapriyadharshini ^{[1
]}

Chang, Jenny C. ^{[2
,3
]}

Glynn, Sharon A. ^{[1
]}

机构：

[1] Univ Galway, Lambe Inst Translat Res, Sch Med, Discipline Pathol, Galway, Ireland

[2] Houston Methodist Res Inst, Houston, TX USA

[3] Houston Methodist Hosp, Dr Mary & Ron Neal Canc Ctr, Houston, TX USA

来源：

FRONTIERS IN PHYSIOLOGY | 2024年 / 15卷

基金：

爱尔兰科学基金会;

关键词：

nitric oxide; cancer; human epidermal growth factor receptor 2; epidermal growth factor receptor; post-translational modification; nitrosation; EPIDERMAL-GROWTH-FACTOR; CELL LUNG-CANCER; C-ERBB-3 PROTEIN EXPRESSION; HUMAN-BREAST-CANCER; TYROSINE KINASE INHIBITOR; JAK-STAT PATHWAY; PHASE-III TRIAL; FACTOR RECEPTOR; EGF-RECEPTOR; ERBB RECEPTORS;

D O I：

10.3389/fphys.2024.1358850

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The human epidermal growth factor receptor (HER) family consists of four members, activated by two families of ligands. They are known for mediating cell-cell interactions in organogenesis, and their deregulation has been associated with various cancers, including breast and esophageal cancers. In particular, aberrant epidermal growth factor receptor (EGFR) and HER2 signaling drive disease progression and result in poorer patient outcomes. Nitric oxide (NO) has been proposed as an alternative activator of the HER family and may play a role in this aberrant activation due to its ability to induce s-nitrosation and phosphorylation of the EGFR. This review discusses the potential impact of NO on HER family activation and downstream signaling, along with its role in the efficacy of therapeutics targeting the family.

引用

页数：19

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