I2-Catalyzed three-component synthesis of 3-selenylated pyrazolo[1,5-a]pyrimidines

被引：4

作者：

Choudhuri, Tathagata ^{[1
]}

Paul, Suvam ^{[1
]}

Sikdar, Papiya ^{[1
]}

Das, Sourav ^{[1
]}

Sawant, Sanghapal D. ^{[2
]}

Bagdi, Avik Kumar ^{[1
]}

机构：

[1] Univ Kalyani, Dept Chem, Kalyani 741235, India

[2] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, India

来源：

NEW JOURNAL OF CHEMISTRY | 2024年 / 48卷 / 21期

关键词：

C-SE; ORGANOSELENIUM; DISELENIDES; SELENIDES; CHEMISTRY; ACCESS;

D O I：

10.1039/d3nj05847f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A straightforward protocol has been developed to access 3-selenylated pyrazolo[1,5-a]pyrimidines from readily available amino pyrazoles, chalcones, and diaryl/dialkyl diselenides. This I-2-catalyzed methodology is highly useful for synthesizing a wide range of functionalized 3-(aryl/alkylselanyl)pyrazolo[1,5-a]pyrimidine derivatives. Mechanistic investigation disclosed that iodine catalysis is very important in both the cyclization process as well as in the C-H selenylation step. Moreover, the developed reaction conditions are also applicable for the cyclization of amino pyrazole with enaminone followed by C-H selenylation in one pot. The use of simple reagents and catalyst, wide substrate scope, mild and metal-free reaction conditions, and practical applicability are the attractive facets of this approach.

引用

收藏

页码：9480 / 9485

页数：6

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