Advances in Organ and Tissue Xenotransplantation

被引：16

作者：

Ali, Asghar ^{[1
,2
,3
]}

Kemter, Elisabeth ^{[1
,2
,3
]}

Wolf, Eckhard ^{[1
,2
,3
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Gene Ctr, Mol Anim Breeding & Biotechnol, Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Dept Vet Sci, Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Ctr Innovat Med Models CiMM, Oberschleissheim, Germany

来源：

ANNUAL REVIEW OF ANIMAL BIOSCIENCES | 2024年 / 12卷

基金：

瑞士国家科学基金会;

关键词：

pig; genetic engineering; xenotransplantation; heart; kidney; pancreatic; islets; PORCINE ISLET XENOTRANSPLANTATION; GENETICALLY-ENGINEERED PIGS; HUMAN NK CYTOTOXICITY; TRANSGENIC PIGS; IN-VITRO; NONHUMAN-PRIMATES; IMMUNE-RESPONSE; DENDRITIC CELLS; GRAFT-SURVIVAL; EXPRESSION;

D O I：

10.1146/annurev-animal-021122-102606

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In recent years, extensive research has been done to explore the possibility of transplanting animal organs into humans, a process referred to as xenotransplantation.Due to their matching organ sizes and other anatomical and physiological similarities with humans, pigs are the preferred organ donor species. Organ rejection due to host immune response and possible interspecies infectious pathogen transmission have been the biggest hurdles to xenotransplantation's success. Use of genetically engineered pigs as tissue and organ donors for xenotransplantation has helped to address these hurdles. Although several preclinical trials have been conducted in nonhuman primates, some barriers still exist and demand further efforts. This review focuses on the recent advances and remaining challenges in organ and tissue xenotransplantation.

引用

页码：369 / 390

页数：22

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