Glycated haemoglobin index is a new predictor for all-cause mortality and cardiovascular mortality in the adults

被引:1
作者
Huang, Yi [1 ]
Huang, Xiantao [2 ]
Zhong, Lingyun [1 ]
Yang, Jingqi [2 ]
机构
[1] Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang, Jiangxi, Peoples R China
[2] Jiangxi Prov Peoples Hosp, Nanchang Med Coll, Affiliated Hosp 1, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Glycosylated haemoglobin index; All-cause mortality; Cardiovascular mortality; US adults; NHANES; ASSOCIATION; ACCORD; TRENDS; A1C;
D O I
10.1038/s41598-024-70666-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Glycosylated haemoglobin index (HGI) has been shown to correlate with the prognosis of metabolic diseases, but the relationship with mortality remains unclear. This study included 18,285 US adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. During the median follow-up period of 115 months, a total of 2572 all-cause deaths and 671 cardiovascular disease (CVD) deaths occurred. The restricted cubic spline revealed a U-shaped correlation between HGI and all-cause and CVD mortality. After adjusting for all covariates, the optimal inflection point values in all-cause and CVD deaths were 0.17 and 0.02, respectively. In the left side of the inflection point, the risk of all-cause mortality and CVD mortality decreased by approximately 24% (HR 0.76, 95% CI 0.69, 0.84) and 25% (HR 0.75, 95% CI 0.60, 0.96) with the increase in HGI. Conversely, in the right of the inflection point, an increase of 1 unit in the HGI was linked with a 17% (HR 1.17, 95% CI 1.07, 1.27) and 31% (HR 1.31, 95% CI 1.15, 1.49) increase in all-cause and CVD mortality. Our study showed that HGI is an important tool for predicting the risk of all-cause mortality and CVD death in US adults and there is a U-shaped relationship between HGI and mortality.
引用
收藏
页数:10
相关论文
共 50 条
[31]   Coffee consumption and all-cause and cardiovascular mortality in Croatia [J].
Jazbec, A ;
Simic, D ;
Corovic, N ;
Malinar, M ;
Pavlovic, M .
ITI 2000: PROCEEDINGS OF THE 22ND INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY INTERFACES, 2000, :317-322
[32]   Geriatric nutrition risk index in the prediction of all-cause and cardiovascular mortality in older adults with hyperlipidemia: NHANES 1999-2018 [J].
Cheng, Kun ;
Zhang, Jing ;
Ye, Lu-Ya ;
Lin, Mou-Hui ;
Ding, Xiao-Yan ;
Zheng, Xiao-E ;
Zhou, Xiao-Fen .
BMC GERIATRICS, 2024, 24 (01)
[33]   Cardiovascular damage phenotypes and all-cause and CVD mortality in older adults [J].
Miller, Lindsay M. ;
Wu, Chenkai ;
Hirsch, Calvin H. ;
Lopez, Oscar L. ;
Cushman, Mary ;
Odden, Michelle C. .
ANNALS OF EPIDEMIOLOGY, 2021, 63 :35-40
[34]   Relations of Anemia With the All-Cause Mortality and Cardiovascular Mortality in General Population: A Meta-Analysis [J].
Liu, Zhou ;
Sun, Rong ;
Li, Jianting ;
Cheng, Wenke ;
Li, Lin .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2019, 358 (03) :191-199
[35]   Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease [J].
Yang, Jin-gang ;
Li, Jue ;
Lu, Changlin ;
Hasimu, Buaijiaer ;
Yang, Yuejin ;
Hu, Dayi .
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2010, 17 (04) :395-401
[36]   Parathyroid hormone, cardiovascular and all-cause mortality: A meta-analysis [J].
Yang, Bo ;
Lu, Changlin ;
Wu, Qing ;
Zhang, Jian ;
Zhao, Hua ;
Cao, Yukang .
CLINICA CHIMICA ACTA, 2016, 455 :154-160
[37]   The triglyceride glucose index was U-shape associated with all-cause mortality in population with cardiovascular diseases [J].
Li, Haiyu ;
Jiang, Yaohui ;
Su, Xin ;
Meng, Zhe .
DIABETOLOGY & METABOLIC SYNDROME, 2023, 15 (01)
[38]   The triglyceride glucose index was U-shape associated with all-cause mortality in population with cardiovascular diseases [J].
Haiyu Li ;
Yaohui Jiang ;
Xin Su ;
Zhe Meng .
Diabetology & Metabolic Syndrome, 15
[39]   Diabetes Mellitus-Related All-Cause and Cardiovascular Mortality in a National Cohort of Adults [J].
Raghavan, Sridharan ;
Vassy, Jason L. ;
Ho, Yuk-Lam ;
Song, Rebecca J. ;
Gagnon, David R. ;
Cho, Kelly ;
Wilson, Peter W. F. ;
Phillips, Lawrence S. .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (04)
[40]   Food Insecurity Is Associated With Cardiovascular and All-Cause Mortality Among Adults in the United States [J].
Sun, Yangbo ;
Liu, Buyun ;
Rong, Shuang ;
Du, Yang ;
Xu, Guifeng ;
Snetselaar, Linda G. ;
Wallace, Robert B. ;
Bao, Wei .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (19)