Synthesis and properties of thermosensitive hydrogel of allyl silk fibroin

被引：0

作者：

Wang B. ^{[1
,2
]}

Liu L. ^{[1
]}

Li J. ^{[2
]}

Lu Y. ^{[2
]}

Cheng D. ^{[2
]}

Jin H. ^{[1
]}

Zhou L. ^{[1
]}

机构：

[1] College of Materials Science and Engineering, Shanghai University, Shanghai

[2] Liaoning Provincial Key Laboratory of Functional Textile Materials, Eastern Liaoning University, Dandong

来源：

Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 12期

关键词：

Elasticity; Hydrogel; Polymerization; Silk fibroin; Thermosensitivity;

D O I：

10.11949/0438-1157.20200626

中图分类号：

学科分类号：

摘要：

For the sake of solving the problems of poor mechanical strength and dissolve-loss ratio of Antheraea pernyi silk fibroin (ASF), allyl silk fibroin (ASF-AGE) was synthesized through nucleophilic substitution using ASF as substrate and allyl glycidyl ether (AGE) as modifier under basic conditions. And a series of gel were manufactured though in situ polymerization using ASF-AGE and N-isopropylacrylamide (NIPAAm) monomer without any crosslinking agent. The amino conversion rate of ASF was confirmed by ninhydrin colorimetry, the molecular structure of ASF-AGE was characterized by 1H NMR and the influence of ASF-AGE content on crystal structure, temperature sensitivity, dissolution stability and mechanical properties of hydrogels were also investigated by XRD, DSC, compression test and so on. The results indicated that allyl was successfully introduced into ASF, the amino conversion rate of ASF was 55.21% when the reaction condition was 1: 8 mass ratio (ASF/AGE), T=20℃ and pH=10.5. The stable hydrogels can be obtained by ASF-AGE and NIPAAm polymerization. The hydrogels showed lower critical solution temperatures (LCST) at about 32℃, which revealed obvious thermosensitive characteristic. When the ratio of ASF-AGE to NIPAAm is 4/6, the hydrogel has good dissolution stability and comprehensive mechanical properties. © 2020, Editorial Board of CIESC Journal. All right reserved.

引用

页码：5821 / 5830

页数：9

共 31 条

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