Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis

被引：0
作者：
Huertos Soto, Nerea [1 ]
Cervantes, Juan Manuel Gomez [2 ,3 ]
Acenero, Maria Jesus Fernandez [4 ]
Beauregard, Maria del Carmen Soto [2 ,3 ]
机构：
[1] Hosp Clin San Carlos IdISSC, Community Madrids Youth Employment Program PEJ 202, Physiopathol & neurol therapy INA NEURO INA IN, Hlth Res Inst, Madrid 21347, Spain
[2] San Carlos Clin Hosp, Pediat Surg Dept, 6th south,Prof Martin Lagos s-n, Madrid, Spain
[3] Hosp Clin San Carlos IdISSC, Hlth Res Inst, Madrid, Spain
[4] San Carlos Clin Hosp, Pathol Dept, Madrid, Spain
来源：
LABORATORY ANIMAL RESEARCH | 2024年 / 40卷 / 01期
关键词：
Enterocolitis; Cannabidiol; Newborn; Intestine; Murine experimental model; PLATELET-ACTIVATING-FACTOR; RAT MODEL; REPERFUSION INJURY; NITRIC-OXIDE; APOPTOSIS; DAMAGE; PATHOPHYSIOLOGY; ISCHEMIA; PROTECTS; NECROSIS;
D O I：
10.1186/s42826-024-00211-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
BackgroundNecrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance.Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC. BackgroundNecrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance.Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC. ResultsMortality and intestinal histological damage was significantly lower in the CBD group compared to the rest (p<0.05), establishing CBD as a protective factor against the development of NEC (OR=0.0255; 95% CI=0.0015-0.4460). At IHQ level (TUNEL technique), a lower cell death rate was also observed in the CBD group compared to the VEH group (p<0.05). ConclusionsIn our experimental model, intraperitoneal CBD acts as a protective factor against NEC, resulting in less histological damage and a lower rate of intestinal cell death.
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页数：11
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