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Multiple functions of HMGB1 in cancer
被引:7
|作者:
Lv, Guangyao
[1
]
Yang, Menglin
[2
]
Gai, Keke
[1
]
Jia, Qiong
[1
]
Wang, Zhenzhen
[1
]
Wang, Bin
[1
]
Li, Xueying
[3
]
机构:
[1] Binzhou Med Univ Hosp, Dept Pharm, Binzhou, Shandong, Peoples R China
[2] Marine Biomed Res Inst Qingdao, Qual Management Dept, Qingdao, Peoples R China
[3] Binzhou Polytech, Sch Hlth, Binzhou, Peoples R China
来源:
关键词:
HMGB1;
cancer;
chemotherapy resistance;
autophagy;
immunotherapy;
GROUP BOX 1;
IMMUNOGENIC CELL-DEATH;
HMGB1-MEDIATED AUTOPHAGY;
PROTEIN HMGB1;
ANGIOGENESIS;
CHEMOTHERAPY;
RESISTANCE;
EXPRESSION;
PROGRESSION;
MIGRATION;
D O I:
10.3389/fonc.2024.1384109
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
High mobility group box 1 (HMGB1) is a nuclear DNA-binding protein with a dual role in cancer, acting as an oncogene and a tumor suppressor. This protein regulates nucleosomal structure, DNA damage repair, and genomic stability within the cell, while also playing a role in immune cell functions. This review comprehensively evaluates the biological and clinical significance of HMGB1 in cancer, including its involvement in cell death and survival, its potential as a therapeutic target and cancer biomarker, and as a prosurvival signal for the remaining cells after exposure to cytotoxic anticancer treatments. We highlight the need for a better understanding of the cellular markers and mechanisms involved in the involvement of HMGB1in cancer, and aim to provide a deeper understanding of its role in cancer progression.
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页数:12
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