Multiple functions of HMGB1 in cancer

被引:7
|
作者
Lv, Guangyao [1 ]
Yang, Menglin [2 ]
Gai, Keke [1 ]
Jia, Qiong [1 ]
Wang, Zhenzhen [1 ]
Wang, Bin [1 ]
Li, Xueying [3 ]
机构
[1] Binzhou Med Univ Hosp, Dept Pharm, Binzhou, Shandong, Peoples R China
[2] Marine Biomed Res Inst Qingdao, Qual Management Dept, Qingdao, Peoples R China
[3] Binzhou Polytech, Sch Hlth, Binzhou, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
HMGB1; cancer; chemotherapy resistance; autophagy; immunotherapy; GROUP BOX 1; IMMUNOGENIC CELL-DEATH; HMGB1-MEDIATED AUTOPHAGY; PROTEIN HMGB1; ANGIOGENESIS; CHEMOTHERAPY; RESISTANCE; EXPRESSION; PROGRESSION; MIGRATION;
D O I
10.3389/fonc.2024.1384109
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
High mobility group box 1 (HMGB1) is a nuclear DNA-binding protein with a dual role in cancer, acting as an oncogene and a tumor suppressor. This protein regulates nucleosomal structure, DNA damage repair, and genomic stability within the cell, while also playing a role in immune cell functions. This review comprehensively evaluates the biological and clinical significance of HMGB1 in cancer, including its involvement in cell death and survival, its potential as a therapeutic target and cancer biomarker, and as a prosurvival signal for the remaining cells after exposure to cytotoxic anticancer treatments. We highlight the need for a better understanding of the cellular markers and mechanisms involved in the involvement of HMGB1in cancer, and aim to provide a deeper understanding of its role in cancer progression.
引用
收藏
页数:12
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