Advanced tumor electric fields therapy: A review of innovative research and development and prospect of application in glioblastoma

BackgroundGlioblastoma multiforme (GBM) is an aggressive malignant tumor with a high mortality rate and is the most prevalent primary intracranial tumor that remains incurable. The current standard treatment, which involves surgery along with concurrent radiotherapy and chemotherapy, only yields a survival time of 14-16 months. However, the introduction of tumor electric fields therapy (TEFT) has provided a glimmer of hope for patients with newly diagnosed and recurrent GBM, as it has been shown to extend the median survival time to 20 months. The combination of TEFT and other advanced therapies is a promising trend in the field of GBM, facilitated by advancements in medical technology.AimsIn this review, we provide a concise overview of the mechanism and efficacy of TEFT. In addition, we mainly discussed the innovation of TEFT and our proposed blueprint for TEFT implementation.ConclusionTumor electric fields therapy is an effective and highly promising treatment modality for GBM. The full therapeutic potential of TEFT can be exploited by combined with other innovative technologies and treatments. The prospect of TEFT plus advanced therapy including PDT, ultrasound device, universal implantable electrodes, NovoTAL System and digital twins (By Figdraw). In combination with a variety of physiotherapy innovations, we envision a multimodal treatment approach that improves TEFT antitumor efficacy, while providing an excellent safety profile.image