Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

被引：0

作者：

Li, Min-shan ^{[1
,2
,3
]}

Wang, Xiang-hong ^{[1
,2
,3
]}

Wang, Heng ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Allergy & Clin Immunol, Tongji Med Coll, Wuhan 430030, Peoples R China

[3] Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan 430030, Peoples R China

来源：

CURRENT MEDICAL SCIENCE | 2024年 / 44卷 / 03期

基金：

中国国家自然科学基金;

关键词：

proton-activated G protein-coupled receptors; inflammation; immunomodulation; disease; AIRWAY SMOOTH-MUSCLE; EXTRACELLULAR ACIDIFICATION; GENE; 8; CYTOKINE PRODUCTION; SENSING TDAG8; ACIDIC PH; T-CELLS; GPR4; OGR1; INHIBITION;

D O I：

10.1007/s11596-024-2872-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

引用

页码：475 / 484

页数：10

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