Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

被引：0

作者：

Li, Min-shan ^{[1
,2
,3
]}

Wang, Xiang-hong ^{[1
,2
,3
]}

Wang, Heng ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Allergy & Clin Immunol, Tongji Med Coll, Wuhan 430030, Peoples R China

[3] Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan 430030, Peoples R China

来源：

CURRENT MEDICAL SCIENCE | 2024年 / 44卷 / 03期

基金：

中国国家自然科学基金;

关键词：

proton-activated G protein-coupled receptors; inflammation; immunomodulation; disease; AIRWAY SMOOTH-MUSCLE; EXTRACELLULAR ACIDIFICATION; GENE; 8; CYTOKINE PRODUCTION; SENSING TDAG8; ACIDIC PH; T-CELLS; GPR4; OGR1; INHIBITION;

D O I：

10.1007/s11596-024-2872-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

引用

页码：475 / 484

页数：10

共 86 条

[11] OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages [J].

D'Souza, Cheryl A. ;

Zhao, Fei Linda ;

Li, Xujian ;

Xu, Yan ;

Dunn, Shannon E. ;

Zhang, Li .

PLOS ONE, 2016, 11 (02)

[12] TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain [J].

Dai, Shih-Ping ;

Hsieh, Wei-Shan ;

Chen, Chien-Hua ;

Lu, Yueh-Hao ;

Huang, Hsu-Shan ;

Chang, Der-Ming ;

Huang, Shir-Ly ;

Sun, Wei-Hsin .

JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)

[13] Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68) [J].

de Valliere, Cheryl ;

Cosin-Roger, Jesus ;

Simmen, Simona ;

Atrott, Kirstin ;

Melhem, Hassan ;

Zeitz, Jonas ;

Madanchi, Mehdi ;

Tcymbarevich, Irina ;

Fried, Michael ;

Kullak-Ublick, Gerd A. ;

Vavricka, Stephan R. ;

Misselwitz, Benjamin ;

Seuwen, Klaus ;

Wagner, Carsten A. ;

Eloranta, Jyrki J. ;

Rogler, Gerhard ;

Rui, Pedro A. .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2016, 2 (06) :796-810

[14] Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells [J].

Dong, Lixue ;

Krewson, Elizabeth A. ;

Yang, Li V. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (02)

[15] Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis [J].

Dong, Lixue ;

Li, Zhigang ;

Leffler, Nancy R. ;

Asch, Adam S. ;

Chi, Jen-Tsan ;

Yang, Li V. .

PLOS ONE, 2013, 8 (04)

[16] Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics [J].

Fagerberg, Linn ;

Hallstrom, Bjorn M. ;

Oksvold, Per ;

Kampf, Caroline ;

Djureinovic, Dijana ;

Odeberg, Jacob ;

Habuka, Masato ;

Tahmasebpoor, Simin ;

Danielsson, Angelika ;

Edlund, Karolina ;

Asplund, Anna ;

Sjostedt, Evelina ;

Lundberg, Emma ;

Szigyarto, Cristina Al-Khalili ;

Skogs, Marie ;

Takanen, Jenny Ottosson ;

Berling, Holger ;

Tegel, Hanna ;

Mulder, Jan ;

Nilsson, Peter ;

Schwenk, Jochen M. ;

Lindskog, Cecilia ;

Danielsson, Frida ;

Mardinoglu, Adil ;

Sivertsson, Asa ;

von Feilitzen, Kalle ;

Forsberg, Mattias ;

Zwahlen, Martin ;

Olsson, IngMarie ;

Navani, Sanjay ;

Huss, Mikael ;

Nielsen, Jens ;

Ponten, Fredrik ;

Uhlen, Mathias .

MOLECULAR & CELLULAR PROTEOMICS, 2014, 13 (02) :397-406

[17] International Union of Pharmacology. XLVI. G protein-coupled receptor list [J].

Foord, SM ;

Bonner, TI ;

Neubig, RR ;

Rosser, EM ;

Pin, JP ;

Davenport, AP ;

Spedding, M ;

Harmar, AJ .

PHARMACOLOGICAL REVIEWS, 2005, 57 (02) :279-288

[18] Neutrophils Regulate Tissue Neutrophilia in Inflammation via the Oxidant-modified Lipid Lysophosphatidylserine [J].

Frasch, S. Courtney ;

Fernandez-Boyanapalli, Ruby F. ;

Berry, Karin A. Zemski ;

Murphy, Robert C. ;

Leslie, Christina C. ;

Nick, Jerry A. ;

Henson, Peter M. ;

Bratton, Donna L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (07) :4583-4593

[19] The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints [J].

Fredriksson, R ;

Lagerström, MC ;

Lundin, LG ;

Schiöth, HB .

MOLECULAR PHARMACOLOGY, 2003, 63 (06) :1256-1272

[20] Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity [J].

Gaublomme, Jellert T. ;

Yosef, Nir ;

Lee, Youjin ;

Gertner, Rona S. ;

Yang, Li V. ;

Wu, Chuan ;

Pandolfi, Pier Paolo ;

Mak, Tak ;

Satija, Rahul ;

Shalek, Alex K. ;

Kuchroo, Vijay K. ;

Park, Hongkun ;

Regev, Aviv .

CELL, 2015, 163 (06) :1400-1412

← 1 2 3 4 5 6 7 8 9 →