Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

被引：0
作者：
Li, Min-shan [1 ,2 ,3 ]
Wang, Xiang-hong [1 ,2 ,3 ]
Wang, Heng [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Allergy & Clin Immunol, Tongji Med Coll, Wuhan 430030, Peoples R China
[3] Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan 430030, Peoples R China
来源：
CURRENT MEDICAL SCIENCE | 2024年 / 44卷 / 03期
基金：
中国国家自然科学基金;
关键词：
proton-activated G protein-coupled receptors; inflammation; immunomodulation; disease; AIRWAY SMOOTH-MUSCLE; EXTRACELLULAR ACIDIFICATION; GENE; 8; CYTOKINE PRODUCTION; SENSING TDAG8; ACIDIC PH; T-CELLS; GPR4; OGR1; INHIBITION;
D O I：
10.1007/s11596-024-2872-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.
引用
收藏
页码：475 / 484
页数：10
相关论文
共 86 条
[1]   CLONING, SEQUENCING AND TISSUE DISTRIBUTION OF 2 RELATED G-PROTEIN-COUPLED RECEPTOR CANDIDATES EXPRESSED PROMINENTLY IN HUMAN LUNG-TISSUE [J].
AN, SZ ;
TSAI, C ;
GOETZL, EJ .
FEBS LETTERS, 1995, 375 (1-2) :121-124
[2]   Ionotropic and Metabotropic Proton-Sensing Receptors Involved in Airway Inflammation in Allergic Asthma [J].
Aoki, Haruka ;
Mogi, Chihiro ;
Okajima, Fumikazu .
MEDIATORS OF INFLAMMATION, 2014, 2014
[3]   Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 on Dendritic Cells Is Required for Airway Responses in a Murine Asthma Model [J].
Aoki, Haruka ;
Mogi, Chihiro ;
Hisada, Takeshi ;
Nakakura, Takashi ;
Kamide, Yosuke ;
Ichimonji, Isao ;
Tomura, Hideaki ;
Tobo, Masayuki ;
Sato, Koichi ;
Tsurumaki, Hiroaki ;
Dobashi, Kunio ;
Mori, Tetsuya ;
Harada, Akihiro ;
Yamada, Masanobu ;
Mori, Masatomo ;
Ishizuka, Tamotsu ;
Okajima, Fumikazu .
PLOS ONE, 2013, 8 (11)
[4]   Ogerin mediated inhibition of TGF-β(1) induced myofibroblast differentiation is potentiated by acidic pH [J].
Bell, Tyler J. ;
Nagel, David J. ;
Woeller, Collynn F. ;
Kottmann, R. Mathew .
PLOS ONE, 2022, 17 (07)
[5]   G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis [J].
Bolick, David T. ;
Skaflen, Marcus D. ;
Johnson, Laura E. ;
Kwon, Seong-Chun ;
Howatt, Deborah ;
Daugherty, Alan ;
Ravichandran, Kodi S. ;
Hedrick, Catherine C. .
CIRCULATION RESEARCH, 2009, 104 (03) :318-U84
[6]   Moderate L-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance [J].
Cai, Hao ;
Wang, Xin ;
Zhang, Zhixin ;
Chen, Juan ;
Wang, Fangbin ;
Wang, Lu ;
Liu, Jian .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (04)
[7]   Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts [J].
Chen, Aaron C-H ;
Arany, Praveen R. ;
Huang, Ying-Ying ;
Tomkinson, Elizabeth M. ;
Sharma, Sulbha K. ;
Kharkwal, Gitika B. ;
Saleem, Taimur ;
Mooney, David ;
Yull, Fiona E. ;
Blackwell, Timothy S. ;
Hamblin, Michael R. .
PLOS ONE, 2011, 6 (07)
[8]   pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells [J].
Chen, Xiangjun ;
Jaiswal, Alok ;
Costliow, Zachary ;
Herbst, Paula ;
Creasey, Elizabeth A. ;
Oshiro-Rapley, Noriko ;
Daly, Mark J. ;
Carey, Kimberly L. ;
Graham, Daniel B. ;
Xavier, Ramnik J. .
NATURE IMMUNOLOGY, 2022, 23 (07) :1063-+
[9]   Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells [J].
Choi, JW ;
Lee, SY ;
Choi, YW .
CELLULAR IMMUNOLOGY, 1996, 168 (01) :78-84
[10]   Molecular mechanisms underlying cyclic AMP inhibition of macrophage dependent TNF-α production and neurotoxicity in response to amyloidogenic C-terminal fragment of Alzheimer's amyloid precursor protein [J].
Chong, YH ;
Shin, SA ;
Lee, HJ ;
Kang, JHL ;
Suh, YH .
JOURNAL OF NEUROIMMUNOLOGY, 2002, 133 (1-2) :160-174
123456789