From diabetes to diverse domains: the multifaceted roles of GLP-1 receptor agonists

被引：1

作者：

Dave, Bhavarth P. ^{[1
]}

Chorawala, Mehul R. ^{[1
]}

Shah, Ishika V. ^{[1
]}

Shah, Nidhi N. ^{[1
]}

Bhagat, Shivam U. ^{[1
]}

Prajapati, Bhupendra G. ^{[2
,4
]}

Thakkar, Pratik C. ^{[3
]}

机构：

[1] LM Coll Pharm, Dept Pharmacol & Pharm Practice, Opp Gujarat Univ, Ahmadabad 380009, Gujarat, India

[2] Ganpat Univ, Shree SK Patel Coll Pharmaceut Educ & Res, Dept Pharmaceut & Pharmaceut Technol, Mehsana, Gujarat, India

[3] Univ Auckland, Fac Med & Hlth Sci, Manaaki Manawa Ctr Heart Res, Dept Physiol, 85 Pk Rd, Auckland 1142, New Zealand

[4] Silpakorn Univ, Fac Pharm, Nakhon Pathom 73000, Thailand

来源：

MOLECULAR BIOLOGY REPORTS | 2024年 / 51卷 / 01期

关键词：

GLP-1 receptor agonists; Diabetes; Stroke; Neuroprotective; Cardioprotective; Hepatoprotective; Renoprotective; GLUCAGON-LIKE PEPTIDE-1; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR OUTCOMES; DOPAMINERGIC-NEURONS; COMBINATION THERAPY; PARKINSONS-DISEASE; CLINICAL-OUTCOMES; ORAL SEMAGLUTIDE; OPEN-LABEL; LIRAGLUTIDE;

D O I：

10.1007/s11033-024-09793-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucagon-like Peptide-1 (GLP-1) receptor agonists (GLP-1RAs) emerged as a primary treatment for type-2 diabetes mellitus (T2DM), however, their multifaceted effects on various target organs beyond glycemic control opened a new era of treatment. We conducted a comprehensive literature search using databases including Scopus, Google Scholar, PubMed, and the Cochrane Library to identify clinical, in-vivo, and in-vitro studies focusing on the diverse effects of GLP-1 receptor agonists. Eligible studies were selected based on their relevance to the varied roles of GLP-1RAs in T2DM management and their impact on other physiological functions. Numerous studies have reported the efficacy of GLP-1RAs in improving outcomes in T2DM, with demonstrated benefits including glucose-dependent insulinotropic actions, modulation of insulin signaling pathways, and reductions in glycemic excursions. Additionally, GLP-1 receptors are expressed in various tissues and organs, suggesting their widespread physiological functions beyond glycemic control potentially include neuroprotective, anti-inflammatory, cardioprotective, and metabolic benefits. However, further scientific studies are still underway to maximize the benefits of GLP-1RAs and to discover additional roles in improving health benefits. This article sought to review not only the actions of GLP1RAs in the treatment of T2DM but also explore its effects on potential targets in other disorders.

引用

页数：23