Longitudinal Assessment of Oxidative Stress Markers in Women with Preeclampsia

被引:0
作者
Godhamgaonkar, Aditi [1 ]
Dangat, Kamini [1 ]
Randhir, Karuna [1 ]
Chhetri, Sunaina [1 ]
Shelke, Kajal [1 ]
Shukla, Divya [1 ]
Wagh, Girija [2 ]
Lalwani, Sanjay [2 ]
Gupte, Sanjay [3 ]
Joshi, Sadhana [1 ]
机构
[1] Bharati Vidyapeeth Deemed Univ, ICMR Collaborating Ctr Excellence ICMR CCoE, Interact Res Sch Hlth Affairs, Mother & Child Hlth, Pune Satara Rd, Pune 411043, India
[2] Bharati Vidyapeeth Deemed Univ, Bharati Med Coll & Hosp, Dept Obstet & Gynaecol, Pune 411043, India
[3] Gupte Hosp & Res Ctr, Pune 411004, India
关键词
Oxidative stress; Malondialdehyde; Protein carboxyl; 8-Oxo-2'-deoxyguanosine; Preeclampsia; Pregnancy; EARLY-PREGNANCY; DNA-DAMAGE; PLASMA; MALONDIALDEHYDE; OMEGA-3-FATTY-ACIDS; ASSOCIATION; ACID;
D O I
10.1007/s43032-024-01574-z
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Preeclampsia (PE) is a pregnancy-specific disorder and a major contributor to maternal and fetal morbidity and mortality. Role of oxidative stress in early pregnancy with the pathophysiology of the disorder is unclear. The current study aims to analyse maternal levels of oxidative stress markers (MDA and protein carbonyl) longitudinally across gestation and placental levels of oxidative stress markers (MDA, protein carbonyl and 8-oxo-2'-deoxyguanosine) in women with PE and compare them with non-PE women. 324 pregnant women (216 non-PE and 108 PE women) were longitudinally followed during pregnancy. Women with preeclampsia were stratified as early onset preeclampsia (EOP) and late onset preeclampsia (LOP) Maternal blood at four time points across gestation (11-14 weeks, 18-22 weeks, 26-28 weeks, and at delivery) and placenta were collected. Maternal and placental levels of oxidative stress markers were assessed using commercially available kits. Maternal plasma MDA and protein carbonyl levels were comparable between the PE and non-PE group at all timepoints across gestation. Maternal plasma MDA were significantly higher levels at 26-28 weeks in EOP women when compared to non-PE women (p < 0.05). Placental 8-oxo-dG levels were lower in the EOP group as compared to non-PE (p < 0.05). Elevated plasma MDA levels were positively associated with birth length at 18-22 weeks and 26-28 weeks in the PE group (p < 0.05 for both). Maternal plasma MDA levels were positively associated with systolic blood pressure at 18-22 weeks. Oxidative stress in early pregnancy is not associated with risk of PE.
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收藏
页码:2731 / 2740
页数:10
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