An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

被引：2

作者：

Kim, Jaewon ^{[1
]}

Yoo, Jiyoung ^{[1
]}

Kim, Byungkook ^{[1
]}

Lee, Kyung-Woo ^{[1
]}

Kim, Sunghyun ^{[2
]}

Hong, Sukwon ^{[2
]}

Kim, Jong Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 02841, South Korea

[2] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 41期

基金：

新加坡国家研究基金会;

关键词：

NITRIC-OXIDE; LIVE CELLS; BIOCHEMISTRY; FLUCTUATION;

D O I：

10.1039/d4cc01231c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro. Presenting Mt-NI-2: a fluorescent probe for peroxynitrite levels in human serum and mitochondria. It utilizes as a diagnostic tool for neurodegenerative diseases, facilitating in-depth exploration of their underlying mechanisms.

引用

页码：5443 / 5446

页数：4

共 50 条

[1] AIE-based fluorescent boronate probe and its application in peroxynitrite imaging
Li, Minglu
Han, Hui
Song, Shengmei
Shuang, Shaomin
Dong, Chuan
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 261
[2] An AIE-based self-assembled fluorescent probe for COX-2 imaging
Cao, Xiaozheng
Gao, Tang
Dong, Jie
Jiang, Xinchen
Zou, Hui
Liu, Tingting
Yu, Kundian
Zeng, Wenbin
NEW JOURNAL OF CHEMISTRY, 2019, 43 (20) : 7874 - 7880
[3] An AIE-based Fluorescent Probe for Detection of Picric Acid in Water
Wang, Zhonglin
Si, Shufan
Luo, Zijie
Qin, Tianyi
Xu, Zhongyong
Liu, Bin
CHEMISTRY LETTERS, 2021, 50 (01) : 103 - 105
[4] Ratiometric imaging of butyrylcholinesterase activity in mice with nonalcoholic fatty liver using an AIE-based fluorescent probe
Xiang, Chunbai
Xiang, Jingjing
Yang, Xing
Li, Chunbin
Zhou, Lihua
Jiang, Daoyong
Peng, Yonglin
Xu, Zhen
Deng, Guanjun
Zhu, Baode
Zhang, Pengfei
Cai, Lintao
Gong, Ping
JOURNAL OF MATERIALS CHEMISTRY B, 2022, 10 (22) : 4254 - 4260
[5] An AIE-based ratiometric fluorescent probe for reversible detection of bisulfite and hydrogen peroxide and its application in food samples and biological imaging
Yao, Xinya
Li, Ying
Guo, Yuetian
Zhong, Keli
Tang, Lijun
Yan, Xiaomei
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2024, 446
[6] A specific AIE and ESIPT fluorescent probe for peroxynitrite detection and imaging in living cells
Shen, Youming
Li, Mengyue
Yang, Ming
Zhang, Youyu
Li, Haitao
Zhang, Xiangyang
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2019, 222
[7] An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems
Shi, Lei
Liu, Yan-Hong
Li, Kun
Sharma, Amit
Yu, Kang-Kang
Ji, Myung Sun
Li, Ling-Ling
Zhou, Qian
Zhang, Hong
Kim, Jong Seung
Yu, Xiao-Qi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (25) : 9962 - 9966
[8] A novel ratiometric AIE-based fluorescent probe for specific detection of Hcy/Cys and imaging of living cells in vivo
Lv, Hong-Min
Jiang, Zi-Ke
Wang, Jing
Wang, Tao
Zhang, Xiao-Nan
Hu, Yi-Meng
Ma, Yan-Yan
NEW JOURNAL OF CHEMISTRY, 2021, 45 (41) : 19521 - 19530
[9] A fluorescent probe directly detect peroxynitrite based on boronate oxidation and its applications for fluorescence imaging in living cells
Yu, Fabiao
Song, Ping
Li, Peng
Wang, Bingshuai
Han, Keli
ANALYST, 2012, 137 (16) : 3740 - 3749
[10] AIE-Based Theranostic Probe for Sequential Imaging and Killing of Bacteria and Cancer Cells
Chen, Xiaohui
Huang, Letao
Jia, Yongguang
Hu, Rong
Gao, Meng
Ren, Li
Tang, Ben Zhong
ADVANCED OPTICAL MATERIALS, 2020, 8 (14)

← 1 2 3 4 5 →