Tri-butyltin(IV)phenoxyacetohydroxamate: Synthesis, characterization, biological evaluation and molecular docking studies

被引：1
作者：
Sharma, Vandna [1 ]
Choudhary, Vineet Kumar [1 ]
机构：
[1] IEC Univ Baddi, Dept Chem, Solan 174103, Himachal Prades, India
来源：
MAIN GROUP CHEMISTRY | 2024年 / 23卷 / 01期
关键词：
Tri-butyltin(IV)phenoxyacetohydroxamate complex; spectral studies; antimicrobial activity; molecular docking; ORGANOTIN(IV) COMPLEXES; ANTIBACTERIAL; DERIVATIVES; ACIDS;
D O I：
10.3233/MGC-230008
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The tri-organotin(IV) complex of composition [n-Bu3Sn(C6H5OCH2CONHO)] has been synthesized by using Bu3SnCl and potassium phenoxyacetohydroxamate ligand (KPAH) in pre-determined molar ratio of methanol and tetrahydrofuran. These are characterized by spectral techniques like FTIR, (1) H NMR and mass spectrometry. Studies on electrochemical processes are carried out using cyclic voltammetry. The in vitro antibacterial and antifungal activities performed by using minimum inhibitory concentration (MIC) method has revealed complex as biologically active. Molecular docking of the ligand and complex has been performed against the fungal receptor (PDB ID: 1UKC) to study the interactions between compound and receptor.
引用
收藏
页码：103 / 111
页数：9
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