Effects of Argatroban on Hcy, hs-CRP and FIB levels in patients with acute cerebral infarction

被引：1
作者：
Yang, Bingjian [1 ]
Rui, Chen [2 ]
Liu, Hua [3 ]
Dong, Aiqin [1 ]
Zhang, Yushan [4 ]
Cui, Cuicui [1 ]
Wang, Wenhui [1 ]
机构：
[1] Cangzhou Cent Hosp, Neurol Dept 3, Cangzhou, Peoples R China
[2] Hebei Univ Technol, Econ & Management Coll Cangzhou Cent Hosp, Refined Management Off, Tianjin, Peoples R China
[3] Cangzhou Cent Hosp, Cardiovasc Dept 2, Cangzhou, Peoples R China
[4] Cangzhou Cent Hosp, Neurol Dept 7, Cangzhou, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2024年
关键词：
Argatroban; acute cerebral infarction; coagulation function; quality of life; clinical curative effect; DIRECT THROMBIN INHIBITOR; STROKE;
D O I：
10.1080/00207454.2024.2347549
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: To evaluate the effects of argatroban on the levels of Hcy, hs-CRP and FIB in patients with acute cerebral infarction (ACI). Methods: A retrospective analysis was performed on 382 patients with ACI who were hospitalized in the Department of Neurology of our hospital from January 2017 to December 2019. Among them, 158 patients received conventional treatment as the control group and 224 patients received combined treatment with argatroban as the study group. NHISS score, mRS score, Hcy, hs-CRP, FIB level, quality of life, adverse reactions were compared between the two groups after treatment. The levels of Hcy and hs-CRP in patients with different mRS scores were compared. Results: A superior clinical efficacy of the study group was observed than the control group (p < 0.05). The study group witnessed a remarkably lower NHISS score, Hcy, hs-CRP and FIB level as compare to the control group (p < 0.05). The ADL and FMA scores in the study group were higher than those in the control group (p < 0.05). The levels of Hcy and hs-CRP in mRS 0-2 patients were lower than those in mRS 3-6 patients (p < 0.05). Conclusion: Argatroban in ACI patients can significantly enhance the clinical efficacy and improve the quality of life. It is closely related to the reduction of Hcy and hs-CRP levels, but the mechanism needs to be further studied.
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页数：8
相关论文
共 29 条
[1]   Efficacy and safety of argatroban in the management of acute ischemic stroke: A systematic literature review and meta-analysis [J].
Al-Salihi, Mohammed Maan ;
Saha, Ram ;
Ayyad, Ali ;
Al-Jebur, Maryam Sabah ;
Al-Salihi, Yezan ;
Roy, Anil ;
Dalal, Shamser Singh ;
Rivet, Dennis ;
Spiotta, Alejandro M. ;
Qureshi, Adnan I. .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2024, 236
[2]   Acute Cardioembolic Cerebral Infarction: Answers to Clinical Questions [J].
Arboix, Adria ;
Alio, Josefina .
CURRENT CARDIOLOGY REVIEWS, 2012, 8 (01) :54-67
[3]   Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice [J].
Bea, Florian ;
Kreuzer, Joerg ;
Preusch, Michael ;
Schaab, Sandra ;
Isermann, Berend ;
Rosenfeld, Michael E. ;
Katus, Hugo ;
Blessing, Erwin .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (12) :2787-2792
[4]   Stroke and Hypertension: An Appraisal from Pathophysiology to Clinical Practice [J].
Buonacera, Agata ;
Stancanelli, Benedetta ;
Malatino, Lorenzo .
CURRENT VASCULAR PHARMACOLOGY, 2019, 17 (01) :72-84
[5]   National Institutes of Health Stroke Scale An Alternative Primary Outcome Measure for Trials of Acute Treatment for Ischemic Stroke [J].
Chalos, Vicky ;
van der Ende, Nadinda A. M. ;
Lingsma, Hester F. ;
Mulder, Maxim J. H. L. ;
Venema, Esmee ;
Dijkland, Simone A. ;
Berkhemer, Olvert A. ;
Yoo, Albert J. ;
Broderick, Joseph P. ;
Palesch, Yuko Y. ;
Yeatts, Sharon D. ;
Roos, Yvo B. W. E. M. ;
van Oostenbrugge, Robert J. ;
van Zwam, Wim H. ;
Majoie, Charles B. L. M. ;
van der Lugt, Aad ;
Roozenbeek, Bob ;
Dippel, Diederik W. J. ;
Fransen, Puck S. S. ;
Beumer, Debbie ;
van den Berg, Lucie A. ;
Schonewille, Wouter J. ;
Vos, Jan Albert ;
Nederkoorn, Paul J. ;
Wermer, Marieke J. H. ;
van Walderveen, Marianne A. A. ;
Staals, Julie ;
Hofmeijer, Jeannette ;
van Oostayen, Jacques A. ;
Nijeholt, Geert J. Lycklama A. ;
Boiten, Jelis ;
Brouwer, Patrick A. ;
Emmer, Bart J. ;
de Bruijn, Sebastiaan F. ;
van Dijk, Lukas C. ;
Kappelle, L. Jaap ;
Lo, Rob H. ;
van Dijk, Ewoud J. ;
de Vries, Joost ;
de Kort, Paul L. M. ;
van Rooij, Willem Jan J. ;
van den Berg, Jan S. P. ;
van Hasselt, Boudewijn A. A. M. ;
Aerden, Leo A. M. ;
Dallinga, Rene J. ;
Visser, Marieke C. ;
Bot, Joseph C. J. ;
Vroomen, Patrick C. ;
Eshghi, Omid ;
Schreuder, Tobien H. C. M. L. .
STROKE, 2020, 51 (01) :282-290
[6]  
Chen J L, 2001, Heart Dis, V3, P189, DOI 10.1097/00132580-200105000-00009
[7]   Argatroban plus aspirin versus aspirin in acute ischemic stroke [J].
Chen, Lei ;
Cao, Shanshan ;
Yang, Junxiu .
NEUROLOGICAL RESEARCH, 2018, 40 (10) :862-867
[8]   Early and long-term outcomes of argatroban use in patients with acute noncardioembolic stroke [J].
Chen, Shumin ;
Cai, Dongchun ;
Huang, Peichu ;
Liu, Jichang ;
Lai, Yuzhi ;
He, Jianfeng ;
Zhou, Liang ;
Sun, Hao .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2020, 198
[9]   The multiarm optimization of stroke thrombolysis phase 3 acute stroke randomized clinical trial: Rationale and methods [J].
Deeds, S. Iris ;
Barreto, Andrew ;
Elm, Jordan ;
Derdeyn, Colin P. ;
Berry, Scott ;
Khatri, Pooja ;
Moy, Claudia ;
Janis, Scott ;
Broderick, Joseph ;
Grotta, James ;
Adeoye, Opeolu .
INTERNATIONAL JOURNAL OF STROKE, 2021, 16 (07) :873-880
[10]  
Li F, 2019, NEUROL RES, V41, P498, DOI [10.1080/01616412.2019.1576320, 10.1080/14786419.2019.1675062]
123