Stereoselective Synthesis of β, γ-Fused Bicyclic γ-Ureasultams via an Intramolecular Mannich and aza-Michael Addition Cascade

被引：2

作者：

Yin, Fucheng ^{[1
]}

Qu, Lailiang ^{[1
,2
]}

Chen, Yifan ^{[1
]}

Luo, Zhongwen ^{[1
]}

Kong, Lingyi ^{[1
]}

Wang, Xiaobing ^{[1
]}

机构：

[1] China Pharmaceut Univ, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China

[2] Xinyang Normal Univ, Xinyang 464000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2024年 / 30卷 / 28期

基金：

中国国家自然科学基金;

关键词：

stereoselective; gamma-ureasultams; Mannich; aza-Michael addition; biotin; DRUG DISCOVERY; CONJUGATE ADDITION; ANNULATED SULTAMS; INHIBITORS; DESIGN; BIOTIN; AUXILIARIES; ANALOGS;

D O I：

10.1002/chem.202400438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel approach has been developed for the synthesis of bicyclic beta, gamma-fused bicyclic gamma-ureasultams containing two consecutive chiral centers through an intramolecular Mannich and aza-Michael addition cascade of alkenyl sulfamides. The straightforward practical procedure and readily available starting materials enable the synthesis of variously substituted ureasultams. In addition, bicyclic gamma-ureasultams is a class of potential biotin analogues.

引用

页数：5

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