Comprehending phenotypic plasticity in cancer and evolution

被引：1
|
作者：
Kulkarni, Prakash [1 ,2 ,3 ]
Salgia, Ravi [1 ]
机构：
[1] City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA
[2] City Hope Natl Med Ctr, Dept Syst Biol, Duarte, CA 91010 USA
[3] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
来源：
ISCIENCE | 2024年 / 27卷 / 03期
关键词：
RESISTANCE;
D O I：
10.1016/j.isci.2024.109308
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Organisms as well as cancer cells are adept at adapting to changes in the environment in which they find themselves, by actively adjusting their phenotype. Phenotypic plasticity is a quantitative trait that confers a fitness advantage to the organism by tailoring its phenotype to environmental circumstances. While it is generally held that new traits arise solely from genetic factors, emerging evidence indicates that phenotypic plasticity also plays a critical role both in cancer and evolution. Thus, understanding the mechanisms that underlie phenotypic plasticity can not only provide new insights into organismal evolution and the origin of novelty but can also result in novel strategies and therapeutics to treat cancer.
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页数：5
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