Plasmablastic myeloma transformation of light-chain multiple myeloma

被引：0

作者：

Pakasticali, Nagehan ^{[1
]}

Hortin, Glen L. ^{[2
]}

Li, Julie Y. ^{[2
]}

机构：

[1] Univ S Florida, Dept Pathol & Cell Biol, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2024年 / 64卷 / 02期

关键词：

plasmablastic myeloma; plasmablastic transformation; light chain; multiple myeloma;

D O I：

10.3960/jslrt.24004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasmablastic myeloma (PBM) is an uncommon and aggressive morphologic variant of multiple myeloma (MM). The neoplastic immature cells exhibit diverse morphology, posing a diagnostic challenge. The diagnostic criteria for PBM include the identification of >= 2% plasmablasts in the bone marrow aspirate. This case describes the incidental finding of a light-chain multiple myeloma (LCMM) transformed into PBM, a phenomenon not previously reported.

引用

页码：149 / 151

页数：3

共 10 条

[1] Blastoid plasma cell leukemia mimicking acute leukemia [J].

Fang, Hong ;

Xu, Jie .

BLOOD, 2020, 136 (08) :1012-1012

[2] Plasmablastic morphology - An independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group [J].

Greipp, PR ;

Leong, T ;

Bennett, JM ;

Gaillard, JP ;

Klein, B ;

Stewart, JA ;

Oken, MM ;

Kay, NE ;

Van Ness, B ;

Kyle, RA .

BLOOD, 1998, 91 (07) :2501-2507

[3]

GREIPP PR, 1985, BLOOD, V65, P305

[4] Plasmablastic transformation of multiple myeloma [J].

Lee, CK ;

Ma, ESK ;

Shek, TWH ;

Lam, CCK ;

Au, WY ;

Wan, TSK ;

Chan, LC .

HUMAN PATHOLOGY, 2003, 34 (07) :710-714

[5] Plasma Cell Myeloma and Related Neoplasms [J].

Lorsbach, Robert B. ;

Hsi, Eric D. ;

Dogan, Ahmet ;

Fend, Falko .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2011, 136 (02) :168-182

[6] Light-Chain Multiple Myeloma: A Diagnostic Challenge [J].

Silva, Cristina ;

Costa, Ana ;

Paiva, David ;

Freitas, Sara ;

Alves, Gloria ;

Cotter, Jorge .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (10)

[7] EBV Negative Plasmablastic Transformation of Plasma Cell Myeloma with Aberrant Acquisition of T-Cell Associated Markers: An Aggressive Disease with Very Short Survival [J].

Soliman, Dina Sameh ;

Elsabah, Hesham ;

Ganwo, Ibrahim ;

Al Sabbagh, Ahmad ;

Amer, Aliaa ;

Abbas, Feryal .

BLOOD, 2020, 136

[8] Multiple Auer Rod Like Inclusions in Multiple Myeloma [J].

Tejwani, Narender ;

Tyagi, Seema ;

Dass, Jasmita .

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2017, 33 (01) :121-122

[9]

Vega F, 2005, MODERN PATHOL, V18, P806, DOI 10.1038/modpathol.3800355

[10] Lymphoproliferative Neoplasms With Plasmablastic Morphology An Overview and Diagnostic Approach [J].

Zhou, Jiehao ;

Nassiri, Mehdi .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2022, 146 (04) :407-414

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