The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch

被引：4

作者：

Wang, Qun ^{[1
,3
]}

Hartig, Sean M. ^{[2
]}

Ballantyne, Christie M. ^{[2
]}

Wu, Huaizhu ^{[2
]}

机构：

[1] Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Immunol,Key Lab Infect & ImmunShandong Prov, Jinan 250012, Peoples R China

[2] Baylor Coll Med, Dept Med, One Baylor Plaza,MS BCM285, Houston, TX 77030 USA

[3] Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Immunol, Jinan, Peoples R China

来源：

IMMUNOLOGICAL REVIEWS | 2024年 / 324卷 / 01期

基金：

中国国家自然科学基金;

关键词：

immunity; macrophage; metabolism; obesity; white adipose tissue; REGULATORY T-CELLS; BLOOD LYMPHOCYTE SUBSETS; WEIGHT-LOSS; INSULIN-RESISTANCE; TH17; CELLS; BARIATRIC SURGERY; SEX-DIFFERENCES; INDUCED INFLAMMATION; POTENTIAL ROLE; CUTTING EDGE;

D O I：

10.1111/imr.13338

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

White adipose tissue (WAT) is a vital endocrine organ that regulates energy balance and metabolic homeostasis. In addition to fat cells, WAT harbors macrophages with distinct phenotypes that play crucial roles in immunity and metabolism. Nutrient demands cause macrophages to accumulate in WAT niches, where they remodel the microenvironment and produce beneficial or detrimental effects on systemic metabolism. Given the abundance of macrophages in WAT, this review summarizes the heterogeneity of WAT macrophages in physiological and pathological conditions, including their alterations in quantity, phenotypes, characteristics, and functions during WAT growth and development, as well as healthy or unhealthy expansion. We will discuss the interactions of macrophages with other cell partners in WAT including adipose stem cells, adipocytes, and T cells in the context of various microenvironment niches in lean or obese condition. Finally, we highlight how adipose tissue macrophages merge immunity and metabolic changes to govern energy balance for the organism.

引用

页码：11 / 24

页数：14

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