Effect of sheep bone protein hydrolysate on promoting calcium absorption and enhancing bone quality in low-calcium diet fed rats

被引：0

作者：

Hu, Guanhua ^{[1
,2
]}

Sun, Xueying ^{[1
,2
]}

Hao, Shiqi ^{[1
,2
]}

Li, Xiaotong ^{[1
,2
]}

Qian, Min ^{[1
,2
]}

Dou, Lu ^{[1
,2
]}

Zhang, Min ^{[1
,2
]}

Hou, Puxin ^{[3
]}

Su, Lin ^{[1
,2
]}

Zhao, Lihua ^{[1
,2
]}

Sun, Lina ^{[1
,2
]}

Jin, Ye ^{[1
,2
]}

机构：

[1] College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot,010018, China

[2] Integrative Research Base of Beef and Lamb Processing Technology, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Hohhot,010018, China

[3] Science and Technology Achievement Transformation Center, Bayan nur,015000, China

来源：

Food Chemistry | 2024年 / 446卷

基金：

中国国家自然科学基金;

关键词：

Bone - Chlorine compounds - Diseases - Fatty acids - Hydrolysis - Proteins;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Calcium deficiency is prone to fractures, osteoporosis and other symptoms. In this study, sheep bone protein hydrolysates (SBPHs) were obtained by protease hydrolysis. A low-calcium-diet-induced calcium-deficiency rat model was established to investigate the effects of SBPHs on calcium absorption and intestinal flora composition. The results showed that an SBPHs + CaCl2 treatment significantly increased the bone calcium content, bone mineral density, trabecular bone volume, and trabecular thickness, and reduced trabecular separation, and changed the level of bone turnover markers (P 2 can remarkably enhance the bone mechanical strength, and the microstructure of bone was improved, and the trabecular network was more continuous, complete, and thicker. Additionally, SBPHs + CaCl2 dietary increased the abundance of Firmicutes and reduced the abundance of Proteobacteria and Verrucomicrobiota, and promoted the production of short chain fatty acids. This study indicated that SBPHs promoted calcium absorption and could be applied to alleviate osteoporosis. © 2024 Elsevier Ltd

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