Killer cell immunoglobulin-like receptors in Thai patients with multiple myeloma

被引：4

作者：

Theeranawakam, Aphiradee ^{[1
]}

Vejbaesya, Sasijit ^{[1
,3
]}

Khuhapinant, Archrob ^{[2
]}

Sae-Tam, Pradermchai ^{[1
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Transfus Med, Bangkok, Thailand

[2] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Med, Bangkok, Thailand

[3] Mahidol Univ, Siriraj Hosp, Fac Med, Departmrnt Transfus Med, 2 Wanglang Rd, Bangkok 10700, Thailand

来源：

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY | 2024年 / 42卷 / 01期

关键词：

KIR; multiple myeloma; Thai; NK cell; HLA ligand; CLASS-I; KIR; DIVERSITY; PCR;

D O I：

10.12932/AP-130520-0842

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Natural killer (NK) cells have been implicated in the immune response against multiple myeloma (MM) cells. Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell activity by recognizing specific human leukocyte antigen (HLA) class I as ligands. Objective: To investigate the association of KIR genes and ligands with MM in the Thai population. Methods: KIR gene polymorphisms and their HLA ligands were investigated in 66 Thai patients with MM and 200 healthy controls. Results: The frequencies of KIR3DL1 and 2DS4 were significantly lower in myeloma patients than in controls (P = 0.02). The frequencies of KIR3DL1, 2DS4, 2DL1 with C2, and 3DL1 with Bw4 were significantly higher in the patients achieving > very good partial response (VGPR) than those achieving <= VGPR after treatment with bortezomib (P = 0.009, 0.009, 0.01, and 0.02, respectively). Conclusion: This study suggests the association of KIR genes with the protection against MM and the association of inhibitory KIR and ligands with the response to treatment in MM.

引用

页码：77 / 80

页数：4

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