Decellularized extracellular matrix: A promising strategy for skin repair and regeneration

被引：0
作者：
Jiang S. [1 ]
Zhuang Y. [1 ]
Cai M. [1 ]
Wang X. [1 ]
Lin K. [1 ]
机构：
[1] Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Cent
来源：
Engineered Regeneration | 2023年 / 4卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Bioink; Biomaterial; Decellularization; Extracellular matrix; Skin regeneration;
D O I：
10.1016/j.engreg.2023.05.001
中图分类号：
学科分类号：
摘要：
The skin is an important organ of the human body that resists external threats but lacks sufficient self-regeneration ability when severe damage occurs. However, most of the available skin substitutes cannot achieve ideal restoration of complex structures and multiple functions of native skin tissues. Fortunately, the advent of decellularized extracellular matrix (dECM) offers a promising approach to overcome these obstacles. The dECM, derived from the natural extracellular matrix (ECM), possesses a similar structure and composition, which constructs an environment favorable for cell performance in regeneration. Moreover, dECM retains good bioactivity, low immunogenicity, and high availability, making it a suitable biomaterial for skin repair and regeneration. In this review, various decellularization methods and subsequent evaluations of dECM are introduced first, and the main sources of dECM are then presented. Furthermore, the recent progress of dECM-based biomaterials applied in skin regeneration and future perspectives are summarized. © 2023
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页码：357 / 374
页数：17
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