Effects of propofol, ketamine-propofol mixture in pediatric dental patients undergoing intravenous sedation: a clinical study

被引:0
作者
Isik, Gizem [1 ]
Alpay, Nilgun [2 ]
Daglioglu, Gulcin [3 ]
Ciftci, Volkan [1 ]
机构
[1] Cukurova Univ, Fac Dent, Dept Pediat Dent, TR-01330 Adana, Turkiye
[2] Cukurova Univ, Fac Dent, Dept Anesthesiol & Reanimat, Adana, Turkiye
[3] Cukurova Univ, Balcali Hosp, Dept Biochem, Cent Lab, Adana, Turkiye
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Anxiety; Ketofol; Intravenous sedation; Propofol; Salivary cortisol level; DEPARTMENT PROCEDURAL SEDATION; PROSPECTIVE CASE SERIES; SALIVARY CORTISOL; DEEP SEDATION; KETOFOL; ANALGESIA; COMBINATION; CHILDREN; TRIAL; KETAMINE/PROPOFOL;
D O I
10.1038/s41598-024-61823-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study aimed to evaluate the clinical effects, complications (peri- and postoperative), depth of sedation, recovery times, and changes in anxiety levels in paediatric dental patients receiving intravenous sedation with propofol and ketamine-propofol mixtures. This prospective clinical study included 69 healthy children (ASA 1) aged 3-7 years. The patients were assigned randomly to propofol group (n = 23), which received propofol; 1:3 ketofol group (n = 23), which received 1:3 ketofol; or 1:4 ketofol group (n = 23), which received 1:4 ketofol. The bispectral index (BIS) and Ramsay Sedation Scale (RSS) score were recorded at intervals of 5 min to measure the depth of sedation, and vital signs were evaluated. Peri- and postoperative complications and recovery times were recorded. Anxiety levels were also evaluated using the Facial Image Scale (FIS) and changes in saliva cortisol levels (SCLs) before and after the intravenous sedation procedure. The Kruskal-Wallis test and Wilcoxon signed-rank test were used to determine pre- and posttreatment parameters. Dunn's test for post hoc analysis was used to determine the differences among groups. Children's pre- and posttreatment anxiety levels did not differ significantly according to FIS scores, and increases in SCLs were detected in 1:3 ketofol and 1:4 ketofol groups after dental treatment was completed. Compared with those in the other groups, the BIS values of the patients in 1:4 ketofol indicated a slightly lower depth of sedation. The recovery time of the patients in 1:3 ketofol was longer than that of patients in propofol and 1:4 ketofol. The incidence of postoperative complications (agitation, hypersalivation, nausea/vomiting, and diplopia) did not differ among the groups. Ketamine-propofol combinations provided effective sedation similar to that of propofol infusion without any serious complications during dental treatment performed under intravenous sedation. The ketofol infusion increased the anxiety level of paediatric dental patients to a greater extent than the propofol infusion.
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页数:12
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