Effect of tyrosine kinase inhibitors on male fertility in patients with chronic phase chronic myeloid leukemia

被引：5

作者：

Nesr, George ^{[1
]}

Claudiani, Simone ^{[1
]}

Milojkovic, Dragana ^{[2
]}

Innes, Andrew ^{[1
]}

Fernando, Fiona ^{[2
]}

Caballes, Irene ^{[2
]}

Mungozi, Patience ^{[2
]}

Szydlo, Richard ^{[1
]}

Lovato, Silvia ^{[1
]}

Jayasena, Channa ^{[3
,4
]}

Apperley, Jane ^{[1
]}

机构：

[1] Imperial Coll London, Ctr Haematol, London, England

[2] Imperial Coll Healthcare NHS Trust, Dept Clin Haematol, London, England

[3] Imperial Coll London, Fac Med, Sect Invest Med, London, England

[4] Hammersmith Hosp, Dept Androl, North West London Pathol, London, England

来源：

LEUKEMIA & LYMPHOMA | 2024年 / 65卷 / 08期

关键词：

Chronic myeloid leukemia; tyrosine kinase inhibitors; fertility; semen analysis; IMATINIB MESYLATE; PREGNANCIES; IMPACT;

D O I：

10.1080/10428194.2024.2343758

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advancements in the management of patients with chronic myeloid leukemia (CML) allowed them to achieve survival comparable with their healthy counterparts. Consequently, their care has widened with growing focus on quality of life, including parenting children. Although tyrosine kinase inhibitors (TKI) are contraindicated in pregnancy given their teratogenic effect, their effect on male fertility is less clear with contradictory results from animal studies and case reports/series. We compared the sperm analysis parameters, as the gold-standard assessment for male fertility, of 11 patients with CP- CML before and after TKI therapy. Median therapy duration was 5.1 years (range: 2.5-16.5). The sperm concentration, % progressive, and total motility before and after therapy were not significantly different (p = 0.376, 0.569, and 0.595, respectively). Our results suggest no impairment in fertility potential in male patients after TKI therapy. A larger sample size is crucial to support/refute our findings.

引用

页码：1161 / 1166

页数：6

共 36 条

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