Research progress in the effect of additives on the polymorphic crystallization of amino acids in solution

被引：0
作者：
Su W. [1 ]
Liu X. [1 ]
Hao Q. [1 ]
Guo P. [1 ]
Hao H. [2 ]
Li C. [1 ]
机构：
[1] National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization, School of Chemical Engineering, Hebei University of Technology, Tianjin
[2] School of Chemical Engineering and Technology, Tianjin University, Tianjin
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 08期
关键词：
Additives; Amino acid; Polymorphs; Solution crystallization;
D O I：
10.16085/j.issn.1000-6613.2020-1787
中图分类号：
学科分类号：
摘要：
Different polymorphs of the amino acid often show different physicochemical properties and medicinal effectiveness. Therefore, it is very important to obtain the target polymorphs by regulating the polymorphic crystallization process of amino acid in solution, in which the influence of additives is direct and effective. Thus, in this paper, the effects of various kinds of additives on the process of polymorphic crystallization of amino acid in solution were reviewed. First of all, taking the γ-glycine as an example which couldn't be directly obtained from aqueous solution, the promoting effects of acid, alkali and inorganic salt on the nucleation of the crystal were elucidated, and the mechanism for the effectiveness of these additives on the growth of different polymorphs was analyzed on the perspective of charge compensation. Secondly, the influences of tailor-made additives on the crystal morphology and polymorph of amino acids were expounded. Specifically, the influence of tailor-made additives with different structures on polymorphic transformation was analyzed. Then, the selectivity effects of ethanol-water solvent on the polymorphic crystallization of different amino acids were introduced. Finally, based on the above analysis, the preparation of different target crystal forms by molecular design of additives was prospected. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：4463 / 4472
页数：9
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