Effect of cell therapy with adipose-derived stem cells in the treatment of acute rupture of the Achilles tendon in humans

被引：2

作者：

Vieira, Maria Helena Costa ^{[1
,2
,3
]}

Schweich-Adami, Laynna de Carvalho ^{[2
,3
]}

Oliveira, Rodrigo Juliano ^{[2
,3
,4
]}

Antoniolli-Silva, Andreia Conceicao Milan Brochado ^{[2
,3
,5
]}

机构：

[1] Univ Fed Mato Grosso Do Sul UFMS, Hosp Univ Maria Aparecida Pedrossian HUMAP, Setor Ortopedia & Traumatol, Campo Grande, MS, Brazil

[2] Univ Fed Mato Grosso Do Sul UFMS, Hosp Univ Maria Aparecida Pedrossian HUMAP, Terapia Celular & Genet Toxicol CeTroGen, Ctr Estudos Celulas Tronco, Campo Grande, MS, Brazil

[3] Univ Fed Mato Grosso Do Sul UFMS, Fac Med Dr Helio Madetta FAMED, Programa Posgrad Saude & Desenvolvimento Regiao Ct, Campo Grande, MS, Brazil

[4] Univ Estadual Londrina UEL, Ctr Ciencias Biol CCB, Programa Posgrad Genet & Biol Mol, Londrina, PR, Brazil

[5] Univ Fed Mato Grosso Do Sul, Fac Med, Cidade Univ S-N, Campo Grande, MS, Brazil

来源：

CELL AND TISSUE BANKING | 2024年 / 25卷 / 03期

关键词：

Cell therapy; Achilles tendon; ADSCs; orthopedics; Regenerative medicine;

D O I：

10.1007/s10561-024-10141-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1-rupture; group 2-suture; group 3-rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.

引用

页码：831 / 838

页数：8

共 14 条

[1] Effect of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Application in Achilles-Tendon Injury in an Animal Model [J].

Arnaud-Franco, Angel ;

Lara-Arias, Jorge ;

Marino-Martinez, Ivan A. ;

Cienfuegos-Jimenez, Oscar ;

Barbosa-Quintana, Alvaro ;

Pena-Martinez, Victor M. .

CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (12) :5827-5838

[2] The intra-articular injection of adipose-derived stem cells decreases pain and reduces inflammation in knee osteoarthritis, with or without the addition of platelet-rich plasma also improves functionality [J].

Carvalho Schweich-Adami, Laynna ;

da Silva, Roberto Antoniolli ;

Menezes, Jovino Nogueira da Silva ;

Baranoski, Adrivanio ;

Kassuya, Candida Aparecida Leite ;

Bernardi, Luana ;

Juliano Oliveira, Rodrigo ;

Conceicao Milan Brochado Antoniolli-Silva, Andreia .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2022, 16 (10) :900-912

[3] Autologous bone marrow-derived mesenchymal stem cells provide complete regeneration in a rabbit model of the Achilles tendon bundle rupture [J].

Chailakhyan, Ruben K. ;

Kon, Elizaveta ;

Shekhter, Anatoly B. ;

Ivannikov, Sergey V. ;

Telpukhov, Vladimir I. ;

Grosheva, Alla G. ;

Suslin, Dmitry S. ;

Vorobieva, Nataliya N. ;

Gerasimov, Yury V. ;

Churbanov, Semyon N. ;

Kotova, Svetlana ;

Fayzullin, Alexey L. ;

Lychagin, Alexey V. ;

Lipina, Marina M. ;

Timashev, Peter S. .

INTERNATIONAL ORTHOPAEDICS, 2021, 45 (12) :3263-3276

[4] Ultrasound-Guided Injection Therapy of Achilles Tendinopathy With Platelet-Rich Plasma or Saline: A Randomized, Blinded, Placebo-Controlled Trial [J].

Krogh, Thoger P. ;

Ellingsen, Torkell ;

Christensen, Robin ;

Jensen, Pia ;

Fredberg, Ulrich .

AMERICAN JOURNAL OF SPORTS MEDICINE, 2016, 44 (08) :1990-1997

[5]

Mansur Nacime Salomão Barbachan, 2020, Rev. bras. ortop., V55, P665, DOI 10.1055/s-0040-1702948

[6]

Mansur Nacime Salomão Barbachan, 2020, Rev. bras. ortop., V55, P657, DOI 10.1055/s-0040-1702953

[7] The ultrasonographic appearance of the ruptured Achilles tendon during healing:: a longitudinal evaluation of surgical and nonsurgical treatment, with comparisons to MRI appearance [J].

Möller, M ;

Kälebo, P ;

Tidebrant, G ;

Movin, T ;

Karlsson, J .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2002, 10 (01) :49-56

[8] Vitamin D: Correlation with biochemical and body composition changes in a southern Brazilian population and induction of cytotoxicity in mesenchymal stem cells derived from human adipose tissue [J].

Pesarini, Joao Renato ;

Oliveira, Rodrigo Juliano ;

Pessatto, Lucas Roberto ;

Milan Brochado Antoniolli-Silva, Andreia Conceicao ;

Felicidade, Ingrid ;

Nardi, Nance Beyer ;

Camassola, Melissa ;

Mantovani, Mario Sergio ;

Ribeiro, Lucia Regina .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 91 :861-871

[9] All-trans retinoic acid induces mitochondria-mediated apoptosis of human adipose-derived stem cells and affects the balance of the adipogenic differentiation [J].

Schweich, Laynna de Carvalho ;

Torres de Oliveira, Edwin Jose ;

Pesarini, Joao Renato ;

Hermeto, Larissa Correa ;

Camassola, Melissa ;

Nardi, Nance Beyer ;

Milan Brochado, Themis Maria ;

Milan Brochado Antoniolli-Silva, Andreia Conceicao ;

Oliveira, Rodrigo Juliano .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 96 :1267-1274

[10] Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair [J].

Shen, Hua ;

Yoneda, Susumu ;

Abu-Amer, Yousef ;

Guilak, Farshid ;

Gelberman, Richard H. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2020, 38 (01) :117-127

← 1 2 →