Synthesis, characterization and biological evaluation of some new 2-[(4-hydroxy-6-methylpyrimidin-2-yl)amino]-1-(4-substituted) ethanone derivatives

In this present article, we reported a series of some new 2-[(4-hydroxy-6-methylpyrimidin-2-yl)amino]-1-(4substituted)ethanone derivatives 3(a-d) and the structures were confirmed by IR, NMR and Mass spectroscopic techniques. In vitro alpha-amylase and alpha-glucosidase inhibitory activity results suggested that the compounds 3c and 3d showed good percentage of inhibition. Compound 3d exhibited highest zone of inhibition against P. aeroginosa, E. coli, Shigella and Salmonella. In silico molecular docking study was performed with human lysosomal acid alpha-glucosidase and DNA gyrase proteins. Our synthesized compounds obeyed all five rules without any violations with good bioavailability. Density functional method was applied using Gaussian 09 software. The compounds were optimized through DFT/B3PW91 level with 6-31+G(d,p) basis set.