Per- and polyfluoroalkyl substances and the associated thyroid cancer risk: A case-control study in China

被引：1
作者：
Li H. [1 ,2 ]
Yang M. [3 ,4 ]
Yang J. [1 ]
Seery S. [5 ,6 ]
Ma C. [1 ,2 ]
Liu Y. [1 ,7 ]
Zhang X. [8 ]
Li A. [3 ,4 ]
Guo H. [1 ,7 ]
机构：
[1] Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang
[2] Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang
[3] Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing
[4] Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing
[5] Faculty of Health and Medicine, Division of Health Research, Lancaster University, Lancaster
[6] School of Humanities and Social Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
[7] Hebei Key Laboratory of Environment and Human Health, Hebei Province, Shijiazhuang
[8] Core Facilities and Centers of Hebei Medical University, Shijiazhuang
来源：
Chemosphere | 2023年 / 337卷
基金：
中国国家自然科学基金;
关键词：
Case-control study; Mixture; Per- and polyfluoroalkyl substances; PFAS; Thyroid cancer;
D O I：
10.1016/j.chemosphere.2023.139411
中图分类号：
学科分类号：
摘要：
The role of perfluoroalkyl and polyfluoroalkyl substances (PFAS) as thyroid carcinogens is unclear. Therefore, we intended to identify associations between each PFAS congener and their mixture with thyroid cancer risk. This case-control study of thyroid cancer was conducted in Shijiazhuang, Hebei Province, China. Three hundred participants were recruited from January to May 2022 and were matched according to sex and age. Twelve PFAS were assessed using ultra-high-performance liquid chromatography-tandem mass spectrometry. Associations between PFAS congeners and thyroid cancer risk were considered under conditional logistic regression analysis and a restricted cubic spline model. Mixture effects were also assessed with quantile g-computation and a Bayesian kernel machine regression model. Compared to the first tertile, third tertile PFOA, PFNA, PFHxS, PFDA, and PFUnDA concentrations were associated with lower thyroid cancer risk (ORPFOA: 0.32, 95% confidence interval (CI): 0.15–0.69; ORPFNA: 0.18, 95% CI: 0.07–0.46; ORPFHxS: 0.37, 95% CI: 0.15–0.92; ORPFDA: 0.07, 95% CI: 0.02–0.23; ORPFUnDA: 0.12, 95% CI: 0.05–0.30) after adjusting for confounding factors. PFNA, PFDA, and PFUnDA had a negative dose-response relationship with thyroid cancer risk. Mixture analysis also showed that thyroid cancer risk is negatively associated with the overall mixture and carboxylates. In the overall mixture, PFOS and PFDA contributed most to positive and negative changes in thyroid cancer risk, respectively. However, PFOS, PFNA, PFDA, and PFUnDA were of equally high importance. This study is the first to confirm the effects of the PFAS mixture on thyroid cancer, and further large-scale prospective studies are still warranted to test these inverse associations. © 2023 Elsevier Ltd
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共 77 条
[1]  
Abdel-Rahman O., Prediagnostic BMI and thyroid cancer incidence in the PLCO trial, Future Oncol., 15, pp. 3451-3456, (2019)
[2]  
Arduc A., Dogan B.A., Tuna M.M., Tutuncu Y., Isik S., Berker D., Guler S., Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hurthle-cell lesion/neoplasm fine-needle aspiration diagnosis, Clin. Endocrinol., 83, pp. 405-411, (2015)
[3]  
Toxicological Profile for Perfluoroalkyls, (2018)
[4]  
Barry V., Winquist A., Steenland K., Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant, Environ. Health Perspect., 121, pp. 1313-1318, (2013)
[5]  
Bobb J.F., Bobb M.J.F., Package ‘bkmr’. Bayesian kernel machine regression, R package version 0.2. 0, (2017)
[6]  
Bobb J.F., Valeri L., Claus Henn B., Christiani D.C., Wright R.O., Mazumdar M., Godleski J.J., Coull B.A., Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures, Biostatistics, 16, pp. 493-508, (2015)
[7]  
Bonefeld-Jorgensen E.C., Long M., Bossi R., Ayotte P., Asmund G., Kruger T., Ghisari M., Mulvad G., Kern P., Nzulumiki P., Dewailly E., Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study, Environ. Health, 10, (2011)
[8]  
Bonefeld-Jorgensen E.C., Long M., Fredslund S.O., Bossi R., Olsen J., Breast cancer risk after exposure to perfluorinated compounds in Danish women: a case-control study nested in the Danish National Birth Cohort, Cancer Causes Control, 25, pp. 1439-1448, (2014)
[9]  
Boyd R.I., Ahmad S., Singh R., Fazal Z., Prins G.S., Madak Erdogan Z., Irudayaraj J., Spinella M.J., Toward a mechanistic understanding of poly- and perfluoroalkylated substances and cancer, Cancers, 14, (2022)
[10]  
Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, Ca - Cancer J. Clin., 68, pp. 394-424, (2018)
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