A single-cell and spatially resolved atlas of human osteosarcomas (vol 17, 71, 2024)

被引：0

作者：

Zheng, Xuejing ^{[1
]}

Liu, Xu ^{[1
]}

Zhang, Xinxin ^{[1
]}

Zhao, Zhenguo ^{[1
]}

Wu, Wence ^{[2
]}

Yu, Shengji ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc,Dept Orthoped, Beijing 100021, Peoples R China

[2] Peking Univ First Hosp, Dept Orthoped, Beijing 100021, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2024年 / 17卷 / 01期

关键词：

Osteosarcoma; Single cell; Spatial; Transcriptomics; Tumor heterogeneity;

D O I：

10.1186/s13045-024-01619-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcomas are intricate cellular ecosystems, where heterotypic interactions significantly influence disease progression and therapeutic outcomes. Despite their importance, a detailed understanding of their cellular composition and organizational structure remains elusive. In this study, we provide a comprehensive single-cell and spatially resolved transcriptomics analysis of human osteosarcomas. We construct a cellular meta-map to dissect spatial transcriptomic data, unveiling a detailed atlas of osteosarcoma compositional subgroups. We meticulously characterize the unique gene signatures and functional states of each subgroup and investigate the impact of chemotherapy on these cellular subpopulations. Additionally, our spatial transcriptomics analysis identifies a distinct spatial niche, located at the forefront of tumor necrotic zones, potentially associated with chemotherapy resistance. We also delve into the crosstalk between different cellular subgroups. This study furnishes a comprehensive transcriptional atlas of osteosarcoma's cellular architecture, enriching our comprehension of its complexity and laying the groundwork for more targeted therapeutic approaches.

引用

页数：1