Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors

被引：20
作者：
Camargo, Anny [1 ,2 ]
Ramirez, Juan David [1 ,3 ]
Kiu, Raymond [4 ,5 ]
Hall, Lindsay J. [4 ,5 ,6 ]
Munoz, Marina [1 ,7 ]
机构：
[1] Univ Rosario, Fac Ciencias Nat, Ctr Invest Microbiol & Biotecnol UR CIMBIUR, Bogota, Colombia
[2] Univ Boyaca, Hlth Sci Fac, Tunja, Colombia
[3] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, Mol Microbiol Lab, New York, NY USA
[4] Univ Birmingham, Inst Microbiol & Infect, Coll Med & Dent Sci, Birmingham, England
[5] Norwich Res Pk, Quadram Inst Biosci, Gut Microbes & Hlth, Norwich, England
[6] Univ East Anglia, Norwich Med Sch, Norwich, England
[7] Univ Nacl Colombia, Inst Biotecnol UN IBUN, Bogota, Colombia
来源：
EMERGING MICROBES & INFECTIONS | 2024年 / 13卷 / 01期
关键词：
Clostridium perfringens; genetic diversity; host; enteritis; toxinotypes; toxin type; IOTA-TOXIN; BETA-TOXIN; NUCLEOTIDE-SEQUENCE; NECROTIC ENTERITIS; PERFRINGOLYSIN-O; UNITED-STATES; EPSILON TOXIN; ALPHA-TOXIN; THETA-TOXIN; ENTEROTOXIN;
D O I：
10.1080/22221751.2024.2341968
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with a specific host tropism. Molecular approaches have indicated that most C. perfringens toxins produce membrane pores, leading to osmotic cell disruption and apoptosis. However, identifying mechanisms involved in cell tropism and selective toxicity effects should be studied more. The differential presence and polymorphisms of toxin-encoding genes and genes encoding other virulence factors suggest that molecular mechanisms might exist associated with host preference, receptor binding, and impact on the host; however, this information has not been reviewed in detail. Therefore, this review aims to clarify the current state of knowledge on the structural features and mechanisms of action of the major toxins and virulence factors of C. perfringens and discuss the impact of genetic diversity of toxinotypes in tropism for several hosts.
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页数：11
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