Composition and Function of Neutrophil Extracellular Traps

被引：37
作者：
Wang, Yijie [1 ,2 ,3 ]
Du, Chunjing [4 ]
Zhang, Yue [1 ,2 ,3 ]
Zhu, Liuluan [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China
[2] Beijing Inst Infect Dis, Beijing 100015, Peoples R China
[3] Capital Med Univ, Beijing Ditan Hosp, Natl Ctr Infect Dis, Beijing 100015, Peoples R China
[4] Capital Med Univ, Beijing Ditan Hosp, Dept Crit Care Med, Beijing 100015, Peoples R China
来源：
BIOMOLECULES | 2024年 / 14卷 / 04期
基金：
中国国家自然科学基金;
关键词：
neutrophil extracellular trap; proteins; host defense; cancer; autoimmune diseases; CHROMATIN DECONDENSATION; MITOCHONDRIAL-DNA; HUMAN LACTOFERRIN; CANDIDA-ALBICANS; ELASTASE; RELEASE; NETOSIS; PATHOGENESIS; CONTRIBUTE; MIGRATION;
D O I：
10.3390/biom14040416
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutrophil extracellular traps (NETs) are intricate fibrous structures released by neutrophils in response to specific stimuli. These structures are composed of depolymerized chromatin adorned with histones, granule proteins, and cytosolic proteins. NETs are formed via two distinct pathways known as suicidal NETosis, which involves NADPH oxidase (NOX), and vital NETosis, which is independent of NOX. Certain proteins found within NETs exhibit strong cytotoxic effects against both pathogens and nearby host cells. While NETs play a defensive role against pathogens, they can also contribute to tissue damage and worsen inflammation. Despite extensive research on the pathophysiological role of NETs, less attention has been paid to their components, which form a unique structure containing various proteins that have significant implications in a wide range of diseases. This review aims to elucidate the components of NETs and provide an overview of their impact on host defense against invasive pathogens, autoimmune diseases, and cancer.
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页数：15
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