Hepcidin contributes to largemouth bass ( Micropterus salmoides ) against bacterial infections

被引:3
作者
Zhang, Weixiang [1 ]
Li, Bo [1 ]
Yu, Ruying [1 ]
Xu, Wenyan [2 ]
Liu, Xiaoling [1 ]
Su, Jianguo [1 ]
Yuan, Gailing [1 ]
机构
[1] Huazhong Agr Univ, Coll Fisheries, Dept Aquat Anim Med, Wuhan 430070, Peoples R China
[2] Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou 450046, Peoples R China
关键词
Hepcidin; Micropterus salmoides; Iron regulation; Bacterial diseases; Antimicrobial peptide; GENE; EXPRESSION; RESISTANCE; FISH;
D O I
10.1016/j.ijbiomac.2024.131144
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The increasing emergence and dissemination of bacterial pathogens in largemouth bass culture accelerate the desire for new treatment measures. Antimicrobial peptides as the host ' s antimicrobial source dominate the preferred molecules for discovering antibacterial agents. Here, the potential of Hepcidin-1 from largemouth bass ( Micropterus salmoides ) (MsHep-1) against bacterial infection is demonstrated. MsHep-1 not only improved the survival rate in infection experiments involving Nocardia seriolae (12 %) and Aeromonas hydrophila (18 %) but also coped with iron overload conditions in vivo . Moreover, the antibacterial activity of MsHep-1 in vitro was identified against both gram -negative and gram -positive bacteria. Mechanistic studies show MsHep-1 leads to bacterial death by changing the bacterial membrane potential and disrupting the bacterial membrane structure. These findings demonstrate that MsHep-1 may play an important role in the host response to bacterial infection. It provides promising strategies in the application of immunosuppression prevention and control in fish. AMPs may be a promising and available reservoir for treating the current bacterial diseases.
引用
收藏
页数:11
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