Cerebral Venous Sinus Thrombosis Associated with Vaccine-Induced Thrombotic Thrombocytopenia-A Narrative Review

被引：1

作者：

Scutelnic, Adrian ^{[1
]}

Brodard, Justine ^{[2
]}

Hovinga, Johanna A. Kremer ^{[2
]}

Arnold, Marcel ^{[1
]}

Heldner, Mirjam R. ^{[1
]}

机构：

[1] Bern Univ Hosp, Univ Bern, Dept Neurol, Inselspital, CH-3010 Bern, Switzerland

[2] Univ Bern, Bern Univ Hosp, Inselspital, Dept Hematol, CH-3010 Bern, Switzerland

来源：

CLINICAL AND TRANSLATIONAL NEUROSCIENCE | 2022年 / 6卷 / 02期

关键词：

cerebral venous sinus thrombosis; vaccine-induced immune thrombocytopenia; COVID-19; CHADOX1; NCOV-19; COVID-19;

D O I：

10.3390/ctn6020011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In March 2021, cerebral venous sinus thrombosis and thrombocytopenia after vaccination with adenovirus-based vaccine against SARS-CoV-2 were first reported. The underlining condition has been termed vaccine-induced immune thrombocytopenia (VITT). Anti-platelet factor 4 antibodies have been proposed as a central component of the pathomechanism. Treatment recommendations entailed immunomodulation with intravenous immunoglobulins, avoidance of heparins and avoidance of platelet transfusions. Although mortality from VITT-associated cerebral venous sinus thrombosis has decreased over time, it remains high. The aim of this narrative review is to describe different aspects of this disease according to the current state of knowledge.

引用

页数：9

共 56 条

[1] Comparison of adverse drug reactions among four COVID-19 vaccines in Europe using the EudraVigilance database: Thrombosis at unusual sites [J].

Abbattista, Maria ;

Martinelli, Ida ;

Peyvandi, Flora .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (10) :2554-2558

[2] Three cases of acute venous thromboembolism in females after vaccination for coronavirus disease 2019 [J].

Andraska, Elizabeth A. ;

Kulkarni, Rohan ;

Chaudhary, Mirnal ;

Sachdev, Ulka .

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS, 2022, 10 (01) :14-17

[3]

[Anonymous], Cerebral Venous Thrombosis

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5]

BfArM, BfArM-Startseite

[6] Cerebral Venous Sinus Thrombosis in the US Population, After Adenovirus-Based SARS-CoV-2 Vaccination, and After COVID-19 [J].

Bikdeli, Behnood ;

Chatterjee, Saurav ;

Arora, Shilpkumar ;

Monreal, Manuel ;

Jimenez, David ;

Krumholz, M. Harlan ;

Goldhaber, Z. Samuel ;

Elkind, S. V. Mitchell ;

Piazza, Gregory .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (04) :408-411

[7]

bloomberg, Bloomberg Vaccine Tracker

[8]

Brighton Collaboration, Updated Proposed Brighton Collaboration Process for Developing a Standard Case Definition for Study of New Clinical Syndrome X, as Applied to Thrombosis with Thrombocytopenia Syndrome (TTS)

[9]

British Society for Haematology, About Us

[10] The importance of recognizing cerebral venous thrombosis following anti-COVID-19 vaccination [J].

Ciccone, Alfonso ;

Zanotti, Bruno .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2021, 89 :115-117

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