Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives

被引:43
作者
Rahimi Darehbagh, Ramyar [1 ,2 ,3 ,4 ]
Seyedoshohadaei, Seyedeh Asrin [5 ]
Ramezani, Rojin [1 ]
Rezaei, Nima [6 ,7 ,8 ]
机构
[1] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran
[2] Nanoclub Elites Assoc, Tehran, Iran
[3] Kurdistan Univ Med Sci, Res Inst Hlth Dev, Cellular & Mol Res Ctr, Sanandaj, Iran
[4] Universal Sci Educ & Res Network USERN, Sanandaj, Kurdistan, Iran
[5] Kurdistan Univ Med Sci, Sanandaj, Iran
[6] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran
[7] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Dr Qarib St,Keshavarz Blvd, Tehran 14194, Iran
[8] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran
基金
英国科研创新办公室;
关键词
Stem cell therapy; Neurological disorders; Paracrine effects; Immunomodulation; Clinical translation; TRAUMATIC BRAIN-INJURY; PROTECT MOTOR-NEURONS; SPINAL-CORD-INJURY; CLINICAL-TRIALS; FUNCTIONAL RECOVERY; NERVE REGENERATION; PROMOTE RECOVERY; PROGENITOR CELLS; RAT MODEL; LIFE-SPAN;
D O I
10.1186/s40001-024-01987-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Stem cell-based therapies have emerged as a promising approach for treating various neurological disorders by harnessing the regenerative potential of stem cells to restore damaged neural tissue and circuitry. This comprehensive review provides an in-depth analysis of the current state of stem cell applications in primary neurological conditions, including Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, spinal cord injury (SCI), and other related disorders. The review begins with a detailed introduction to stem cell biology, discussing the types, sources, and mechanisms of action of stem cells in neurological therapies. It then critically examines the preclinical evidence from animal models and early human trials investigating the safety, feasibility, and efficacy of different stem cell types, such as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). While ESCs have been studied extensively in preclinical models, clinical trials have primarily focused on adult stem cells such as MSCs and NSCs, as well as iPSCs and their derivatives. We critically assess the current state of research for each cell type, highlighting their potential applications and limitations in different neurological conditions. The review synthesizes key findings from recent, high-quality studies for each neurological condition, discussing cell manufacturing, delivery methods, and therapeutic outcomes. While the potential of stem cells to replace lost neurons and directly reconstruct neural circuits is highlighted, the review emphasizes the critical role of paracrine and immunomodulatory mechanisms in mediating the therapeutic effects of stem cells in most neurological disorders. The article also explores the challenges and limitations associated with translating stem cell therapies into clinical practice, including issues related to cell sourcing, scalability, safety, and regulatory considerations. Furthermore, it discusses future directions and opportunities for advancing stem cell-based treatments, such as gene editing, biomaterials, personalized iPSC-derived therapies, and novel delivery strategies. The review concludes by emphasizing the transformative potential of stem cell therapies in revolutionizing the treatment of neurological disorders while acknowledging the need for rigorous clinical trials, standardized protocols, and multidisciplinary collaboration to realize their full therapeutic promise.
引用
收藏
页数:20
相关论文
共 254 条
[1]   Human umbilical cord mesenchymal stem cell-derived extracellular vesicles: A novel therapeutic paradigm [J].
Abbaszadeh, Hossein ;
Ghorbani, Farzaneh ;
Derakhshani, Mehdi ;
Movassaghpour, Aliakbar ;
Yousefi, Mehdi .
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (02) :706-717
[2]   Stem Cell-based Therapeutic and Diagnostic Approaches in Alzheimer's Disease [J].
Abdi, Sadaf ;
Javanmehr, Nima ;
Ghasemi-Kasman, Maryam ;
Bali, Hanie Yavarpour ;
Pirzadeh, Marzieh .
CURRENT NEUROPHARMACOLOGY, 2022, 20 (06) :1093-1115
[3]   Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions [J].
Aderinto, Nicholas ;
Abdulbasit, Muili Opeyemi ;
Olatunji, Deji .
ANNALS OF MEDICINE AND SURGERY, 2023, 85 (08) :3943-3954
[4]  
Adiga U., 2023, Int Neurourol J, V27, P88
[5]  
Ahmed S, 2017, INDIAN J PSYCHOL MED, V39, P114, DOI 10.4103/0253-7176.203129
[6]   Traumatic spinal cord injury [J].
Ahuja, Christopher S. ;
Wilson, Jefferson R. ;
Nori, Satoshi ;
Kotter, Mark R. N. ;
Druschel, Claudia ;
Curt, Armin ;
Fehlings, Michael G. .
NATURE REVIEWS DISEASE PRIMERS, 2017, 3
[7]   Traumatic Spinal Cord Injury-Repair and Regeneration [J].
Ahuja, Christopher S. ;
Nori, Satoshi ;
Tetreault, Lindsay ;
Wilson, Jefferson ;
Kwon, Brian ;
Harrop, James ;
Choi, David ;
Fehlings, Michael G. .
NEUROSURGERY, 2017, 80 (03) :S9-S22
[8]   An Update on Psychopharmacological Treatment of Autism Spectrum Disorder [J].
Aishworiya, Ramkumar ;
Valica, Tatiana ;
Hagerman, Randi ;
Restrepo, Bibiana .
NEUROTHERAPEUTICS, 2022, 19 (01) :248-262
[9]   Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease [J].
Al-Gharaibeh, Abeer ;
Culver, Rebecca ;
Stewart, Andrew N. ;
Srinageshwar, Bhairavi ;
Spelde, Kristin ;
Frollo, Laura ;
Kolli, Nivya ;
Story, Darren ;
Paladugu, Leela ;
Anwar, Sarah ;
Crane, Andrew ;
Wyse, Robert ;
Maiti, Panchanan ;
Dunbar, Gary L. ;
Rossignol, Julien .
FRONTIERS IN NEUROSCIENCE, 2017, 11
[10]   Stem Cells: Recent Developments Redefining Epilepsy Therapy [J].
Alayli, Adam ;
Lockard, Gavin ;
Gordon, Jonah ;
Connolly, Jacob ;
Monsour, Molly ;
Schimmel, Samantha ;
Pena, Ike Dela ;
Borlongan, Cesar V. .
CELL TRANSPLANTATION, 2023, 32