Effect of Chitosan and Its Water-Soluble Derivatives on Antioxidant Activity

被引:19
作者
Wang, Zhihua [1 ]
Yan, Yongbin [2 ]
Zhang, Zhengmao [1 ]
Li, Changchun [1 ]
Mei, Lanfei [1 ]
Hou, Ruyi [2 ]
Liu, Xiaodan [2 ]
Jiang, Hongxia [3 ]
机构
[1] Hubei Engn Univ, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan 432000, Peoples R China
[2] Hubei Engn Univ, Sch Chem & Mat Sci, Xiaogan 432000, Peoples R China
[3] Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China
关键词
chitosan; water-soluble derivatives; antioxidant activity; hyperlipidemia; RADICALS SCAVENGING ACTIVITY; OXIDATIVE STRESS; MOLECULAR-WEIGHT; CHLORIDE; MECHANISM; ACID;
D O I
10.3390/polym16070867
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The antioxidant activity of chitosan (CS) and three water-soluble derivatives was analyzed comparatively by in vitro and in vivo experiments, including hydroxypropyl chitosan (HPCS), quaternary ammonium salt of chitosan (HACC), and carboxymethyl chitosan (CMCS). The results show that chitosan and its water-soluble derivatives have a scavenging ability on DPPH radicals, superoxide radicals, and hydroxyl radicals, and a reducing ability. A remarkable difference (p < 0.05) was found for HACC and HPCS compared with CS on DPPH radicals, hydroxyl radicals, and reducing ability. The antioxidant ability of the four chitosan samples was in the order of HPCS > HACC > CMCS > CS. Furthermore, antioxidant activity of all samples increased gradually in a concentration-dependent manner. The in vivo result indicates that oral CS and its derivatives samples result in a decrease in lipid peroxides (LPO) and free fatty acids (FFA) levels in serum with an increase in superoxide dismutase (SOD) activity. Especially for the HPCS and HACC groups, the LPO, FFA, and SOD activity in serum was different significantly in comparison with the high-fat controlgroup (HF) (p < 0.05). These results indicate that chitosan and its derivatives can be used as good antioxidants, and the antioxidant activity might be related to the molecular structure of chitosan derivatives.
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页数:12
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